Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Fic(toxin)
Location 2463950..2464536 Replicon chromosome
Accession NZ_CP059900
Organism Tomitella sp. HY172

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag H4F70_RS11445 Protein ID WP_182357297.1
Coordinates 2464144..2464536 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag H4F70_RS11440 Protein ID WP_182357296.1
Coordinates 2463950..2464147 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H4F70_RS11420 2459396..2459974 - 579 WP_182357292.1 NAD(P)H-dependent oxidoreductase -
H4F70_RS11425 2460232..2462637 + 2406 WP_182357293.1 AAA family ATPase -
H4F70_RS11430 2462711..2463136 - 426 WP_182357294.1 nuclear transport factor 2 family protein -
H4F70_RS11435 2463202..2463879 + 678 WP_182357295.1 winged helix-turn-helix domain-containing protein -
H4F70_RS11440 2463950..2464147 + 198 WP_182357296.1 antitoxin Phd Antitoxin
H4F70_RS11445 2464144..2464536 + 393 WP_182357297.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
H4F70_RS11450 2464720..2465010 + 291 WP_182357298.1 zinc ribbon domain-containing protein -
H4F70_RS11455 2465034..2466281 + 1248 WP_182357299.1 acetamidase/formamidase family protein -
H4F70_RS11460 2466295..2468652 + 2358 WP_182357300.1 FUSC family protein -
H4F70_RS11465 2468672..2469487 - 816 WP_182360352.1 crotonase/enoyl-CoA hydratase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(24-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14172.67 Da        Isoelectric Point: 4.6315

>T169319 WP_182357297.1 NZ_CP059900:2464144-2464536 [Tomitella sp. HY172]
VSDHLDREDVLHAGSIAVGHRLDVRDYGLLDAAVARPRATVFGIDAYEGDFEKAAALLQSLARNHAFVDGNKRTAWASAW
VFLHLNGHELDPSFDVDGAEAFMEQAATHSEMEVPQLASRLRGFALSADD

Download         Length: 393 bp

>T169319 NZ_CP076404:c1252461-1252354 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7092.02 Da        Isoelectric Point: 6.4605

>AT169319 WP_182357296.1 NZ_CP059900:2463950-2464147 [Tomitella sp. HY172]
MPALNVPFTDDEMEAVRAGAAEAEQSLRMFAHDAVLSAADQHKKRVREAAALIASRSSELNRRLA

Download         Length: 198 bp

>AT169319 NZ_CP076404:1252508-1252574 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References