Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 1834373..1835028 Replicon chromosome
Accession NZ_CP059900
Organism Tomitella sp. HY172

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H4F70_RS08640 Protein ID WP_182359847.1
Coordinates 1834603..1835028 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H4F70_RS08635 Protein ID WP_126986478.1
Coordinates 1834373..1834606 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H4F70_RS08610 1830782..1831243 - 462 WP_182359843.1 DUF4411 family protein -
H4F70_RS08615 1831240..1832373 - 1134 WP_182359844.1 ImmA/IrrE family metallo-endopeptidase -
H4F70_RS08620 1833014..1833544 + 531 WP_182359845.1 hypothetical protein -
H4F70_RS08625 1833628..1833870 + 243 WP_182348256.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
H4F70_RS08630 1833867..1834124 + 258 WP_182359846.1 type II toxin-antitoxin system RelE/ParE family toxin -
H4F70_RS08635 1834373..1834606 + 234 WP_126986478.1 Arc family DNA-binding protein Antitoxin
H4F70_RS08640 1834603..1835028 + 426 WP_182359847.1 type II toxin-antitoxin system VapC family toxin Toxin
H4F70_RS08645 1835180..1835428 + 249 WP_182359848.1 GNAT family N-acetyltransferase -
H4F70_RS08650 1835751..1836284 + 534 WP_182360271.1 class I SAM-dependent methyltransferase -
H4F70_RS08655 1836262..1837497 - 1236 WP_182360272.1 MFS transporter -
H4F70_RS08660 1837653..1837997 - 345 WP_182359849.1 VOC family protein -
H4F70_RS08665 1838180..1838833 + 654 WP_182359850.1 dihydrofolate reductase family protein -
H4F70_RS08670 1838772..1839158 - 387 WP_182359851.1 hypothetical protein -
H4F70_RS08675 1839205..1839615 - 411 WP_182348265.1 NUDIX domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(13-40)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 15185.27 Da        Isoelectric Point: 4.7145

>T169318 WP_182359847.1 NZ_CP059900:1834603-1835028 [Tomitella sp. HY172]
VIILDTNVISEIFRPLPEPRVVDWLASLEGDVAITSVTLAELLAGVRRLPDGQRRGELTRRINAALAPYRGGRAVLPFDD
VAADRYADVLVARESTGAPISTADAQIAAICLTHGATCATRNVQDFQHTGVELVDPWKVDA

Download         Length: 426 bp

>T169318 NZ_CP076404:c1251926-1251819 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8228.44 Da        Isoelectric Point: 5.6559

>AT169318 WP_126986478.1 NZ_CP059900:1834373-1834606 [Tomitella sp. HY172]
MSSIIVRGLDDAVKQQLAAQAKEHGRSMEAEVRAILTKAARRPHIGIALLAAAQDVGGVEDLPIPVRDDVARAVDFE

Download         Length: 234 bp

>AT169318 NZ_CP076404:1251973-1252039 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References