Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 1252513..1253147 Replicon chromosome
Accession NZ_CP059900
Organism Tomitella sp. HY172

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H4F70_RS05690 Protein ID WP_182359328.1
Coordinates 1252734..1253147 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H4F70_RS05685 Protein ID WP_182346027.1
Coordinates 1252513..1252737 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H4F70_RS05665 1247895..1249088 - 1194 WP_182346031.1 thiolase domain-containing protein -
H4F70_RS05670 1249112..1250272 - 1161 WP_182359325.1 thiolase domain-containing protein -
H4F70_RS05675 1250290..1251291 - 1002 WP_182359326.1 OB-fold nucleic acid binding domain-containing protein -
H4F70_RS05680 1251401..1252444 + 1044 WP_182359327.1 LLM class F420-dependent oxidoreductase -
H4F70_RS05685 1252513..1252737 + 225 WP_182346027.1 ribbon-helix-helix protein, CopG family Antitoxin
H4F70_RS05690 1252734..1253147 + 414 WP_182359328.1 PIN domain nuclease Toxin
H4F70_RS05695 1253251..1253892 + 642 WP_182346205.1 DedA family protein -
H4F70_RS05700 1253945..1254301 - 357 WP_182346026.1 amino acid permease -
H4F70_RS05705 1254561..1254801 + 241 Protein_1124 plasmid stability protein -
H4F70_RS05710 1255246..1255866 - 621 WP_182346024.1 hypothetical protein -
H4F70_RS05715 1256107..1256967 - 861 WP_182359329.1 crotonase/enoyl-CoA hydratase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-125)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-34)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 14919.14 Da        Isoelectric Point: 8.8557

>T169316 WP_182359328.1 NZ_CP059900:1252734-1253147 [Tomitella sp. HY172]
VTRAPWLIDKSALVRMPDSRDVDEWNNRVRRGLVRIATVTLLEVGYSARSAEGHRSALTTAPIALMPVEHATPAAERRAV
EVQGMLAARGHHRGPSVPDLIIAAVAEHARLTVLHVDRDFELIAEVTGQPVARLAVS

Download         Length: 414 bp

>T169316 NZ_CP076404:c462466-462248 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8166.07 Da        Isoelectric Point: 4.3063

>AT169316 WP_182346027.1 NZ_CP059900:1252513-1252737 [Tomitella sp. HY172]
MADILIRGLDEATVAEIDRRAAESGQSRAEFLRRRLDVEFRSGTDIPVTVDDWRRFGAAAADLGDPSVMGEAWS

Download         Length: 225 bp

>AT169316 NZ_CP076404:c462866-462492 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References