Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 174705..175269 Replicon chromosome
Accession NZ_CP059900
Organism Tomitella sp. HY172

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag H4F70_RS00855 Protein ID WP_182358657.1
Coordinates 174922..175269 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag H4F70_RS00850 Protein ID WP_182358656.1
Coordinates 174705..174935 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H4F70_RS00825 170403..171239 + 837 WP_182358652.1 MBL fold metallo-hydrolase -
H4F70_RS00830 171269..172219 + 951 WP_182358653.1 ABC transporter substrate-binding protein -
H4F70_RS00835 172216..173049 + 834 WP_182358654.1 ABC transporter permease -
H4F70_RS00840 173051..173809 + 759 WP_182349248.1 ABC transporter permease -
H4F70_RS00845 173806..174651 + 846 WP_182358655.1 ABC transporter ATP-binding protein -
H4F70_RS00850 174705..174935 + 231 WP_182358656.1 ribbon-helix-helix domain-containing protein Antitoxin
H4F70_RS00855 174922..175269 + 348 WP_182358657.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
H4F70_RS00860 175340..175804 + 465 WP_182358658.1 pyridoxamine 5'-phosphate oxidase family protein -
H4F70_RS00865 175843..176814 + 972 WP_182358659.1 zinc-binding dehydrogenase -
H4F70_RS00870 176867..178399 - 1533 WP_182358660.1 DHA2 family efflux MFS transporter permease subunit -
H4F70_RS00875 178589..179155 + 567 WP_182360073.1 TetR/AcrR family transcriptional regulator -
H4F70_RS00880 179179..180036 - 858 WP_182358661.1 IclR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-38)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12187.07 Da        Isoelectric Point: 10.6439

>T169315 WP_182358657.1 NZ_CP059900:174922-175269 [Tomitella sp. HY172]
MLRGEVRLVDLEPARGGEADKRRPAVIVSNDGANATAARLGRGVVTVVPVTSNTARVFPFQVLLDTETTGLRIDAKAQAE
QVRSVAVERVGPAIARLPGPVMGAIDDALRLHLQL

Download         Length: 348 bp

>T169315 NZ_CP076404:252301-252699 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8335.12 Da        Isoelectric Point: 3.9251

>AT169315 WP_182358656.1 NZ_CP059900:174705-174935 [Tomitella sp. HY172]
MKISVSLPEEDLEILDTYMRESGLPSRSSAIQRAVRMLRNVDLEDDYAAAWSEWESSGDAGVWESASGDGLADAAR

Download         Length: 231 bp

>AT169315 NZ_CP076404:252005-252298 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References