Detailed information of TA system TA169314

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 4420938..4421498
• Replicon: chromosome
• Accession: NZ_CP059898
• Organism: Streptomyces sp. M54

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A1G6ZRZ7
• Locus tag: H3V39_RS19150
• Protein ID: WP_030117649.1
• Coordinates: 4420938..4421216 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: H3V39_RS19155
• Protein ID: WP_030117648.1
• Coordinates: 4421220..4421498 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H3V39_RS19130	4416136..4416705	+	570	WP_206978041.1	dihydrofolate reductase family protein	-
H3V39_RS19135	4416749..4417837	-	1089	WP_206978042.1	DUF397 domain-containing protein	-
H3V39_RS19140	4418003..4418719	-	717	WP_206978043.1	DUF4232 domain-containing protein	-
H3V39_RS19145	4419257..4420930	+	1674	WP_206978044.1	helix-turn-helix domain-containing protein	-
H3V39_RS19150	4420938..4421216	-	279	WP_030117649.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H3V39_RS19155	4421220..4421498	-	279	WP_030117648.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
H3V39_RS19160	4421855..4422130	+	276	WP_206978045.1	hypothetical protein	-
H3V39_RS19165	4422350..4423603	+	1254	WP_206978046.1	hypothetical protein	-
H3V39_RS19170	4424341..4424763	+	423	WP_051702115.1	peptidoglycan-binding protein	-
H3V39_RS19175	4424897..4425382	+	486	WP_030334330.1	hypothetical protein	-
H3V39_RS19180	4425306..4425749	-	444	WP_206978047.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-89)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (8-64)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10615.27 Da
• Isoelectric Point: 10.4146

>T169314 WP_030117649.1 NZ_CP059898:c4421216-4420938 [Streptomyces sp. M54]
MGHATRFTPHAQRDLLKIPLPEARRILGRLADLQKALDAEDLAGFDVKPLQGHDARWRLRVGDYRAVYTVEDGRLIVWVL
AVGHRREIYRAF

Nucleotide

• Length: 279 bp

>T169314 NZ_CP076404:c246239-245961 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10504.68 Da
• Isoelectric Point: 4.5540

>AT169314 WP_030117648.1 NZ_CP059898:c4421498-4421220 [Streptomyces sp. M54]
MSEPVTESMAEVRKHLADVIDRARRDETPTIITRRGKSEAVLVDIDEYRRLRETAERYEDEWLNRLADKAEAEGTNGSVS
LEEMAALLRSAN

Nucleotide

• Length: 279 bp

>AT169314 NZ_CP076404:c246502-246242 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Structures

Toxin

• AlphaFold DB: A0A1G6ZRZ7