Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4832802..4833318 Replicon chromosome
Accession NZ_CP059889
Organism Klebsiella pneumoniae subsp. pneumoniae strain KP18069

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag H4N62_RS23255 Protein ID WP_004178374.1
Coordinates 4832802..4833086 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag H4N62_RS23260 Protein ID WP_002886901.1
Coordinates 4833076..4833318 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H4N62_RS23230 4828286..4828594 - 309 WP_022631369.1 PTS sugar transporter subunit IIB -
H4N62_RS23235 4828679..4828852 + 174 WP_032408826.1 hypothetical protein -
H4N62_RS23240 4828855..4829598 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
H4N62_RS23245 4829955..4832093 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
H4N62_RS23250 4832334..4832798 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
H4N62_RS23255 4832802..4833086 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H4N62_RS23260 4833076..4833318 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
H4N62_RS23265 4833396..4835306 - 1911 WP_004178373.1 BglG family transcription antiterminator -
H4N62_RS23270 4835329..4836483 - 1155 WP_004178372.1 lactonase family protein -
H4N62_RS23275 4836550..4837290 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T169302 WP_004178374.1 NZ_CP059889:c4833086-4832802 [Klebsiella pneumoniae subsp. pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T169302 NZ_CP076382:1140119-1140490 [Mycobacterium intracellulare ATCC 13950]
GTGATCCTCGTTGACACATCGATATGGATTGACCATCTGCACGTCGCCGAGCAGCGCCTCGTCGGCCGCTTGACCAACGA
CGAAATCGGTTGCCACCAAATGGTGATCGAGGAGCTGGCACTCGGTATGATCAAGCAGCGCGACGACGTACTGAGATTGC
TGTCCCATCTGCGCGAGTTTCCGTTGTTGACGCACGCGGAAATCCTCCATCTCGTTGACCGTCGCCGCTTGTGGGGAAGG
GGATTGAGTGCAATCGACGCCCACCTTCTTGGGTCGGTTGCTGTCGTCGACGGTGCACGGCTTTGGACGAGGGACAAGAA
GTTGAAAGCGGCGTGTAAAGAAGTGGGTGTTGCGATCGTCGATGAGTCGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT169302 WP_002886901.1 NZ_CP059889:c4833318-4833076 [Klebsiella pneumoniae subsp. pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT169302 NZ_CP076382:1139926-1140132 [Mycobacterium intracellulare ATCC 13950]
ATGAGGACAACAGTGACCATCGACGATGCCTTACTGGCTCAGGCGGCGGAACTGACCGGCGTGACGGAGAGTGCGGCGCT
TCTCCGTCAGGGATTGCAGACCCTCATTCGGGTAGAGAGCGCCCGCCGTCTCGCGGCGCTCGGCGGCACGGACCCCAAGG
CGTCGGCCGCCCCGCGGCGGAGGCCGCCGACCCGTGATCCTCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References