Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 4722237..4723047 Replicon chromosome
Accession NZ_CP059889
Organism Klebsiella pneumoniae subsp. pneumoniae strain KP18069

Toxin (Protein)


Gene name KacT Uniprot ID A0A060VJ83
Locus tag H4N62_RS22815 Protein ID WP_004178461.1
Coordinates 4722237..4722770 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID J2E9Q7
Locus tag H4N62_RS22820 Protein ID WP_002887278.1
Coordinates 4722781..4723047 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H4N62_RS22810 4721068..4722189 + 1122 WP_002887282.1 cupin domain-containing protein -
H4N62_RS22815 4722237..4722770 - 534 WP_004178461.1 GNAT family N-acetyltransferase Toxin
H4N62_RS22820 4722781..4723047 - 267 WP_002887278.1 DUF1778 domain-containing protein Antitoxin
H4N62_RS22825 4723150..4724583 - 1434 WP_004178459.1 Cu(+)/Ag(+) sensor histidine kinase -
H4N62_RS22830 4724573..4725256 - 684 WP_002887273.1 copper response regulator transcription factor CusR -
H4N62_RS22835 4725428..4726813 + 1386 WP_004178457.1 efflux transporter outer membrane subunit -
H4N62_RS22840 4726831..4727175 + 345 WP_004197273.1 cation efflux system protein CusF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(91-151)

Antitoxin

Vibrio phage ICP1, Orf50

(2-86)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19810.65 Da        Isoelectric Point: 5.2614

>T169301 WP_004178461.1 NZ_CP059889:c4722770-4722237 [Klebsiella pneumoniae subsp. pneumoniae]
MEQQLTIEMIADAFSYDITGFDCGEEALNTFLKEHLKRQHDGQILRGYALVSGDTVPRLLGYYTLSGSCFERGMLPSKTQ
QKKIPYQNAPSVTLGRLAIDKSVQGQGWGEMLVAHAMRVVWGASKAVGIYGLFVEALNEKAKAFYLRLGFIQLVDENSNL
LFYPTKSIEQLFTDDES

Download         Length: 534 bp

>T169301 NZ_CP076382:887734-888195 [Mycobacterium intracellulare ATCC 13950]
ATGGCCAAGCTTTCCGGATCCATCGATGTCCCGCTGCCGCCCGAGGTGGCCTGGCAGCACGCCTCCGACCTGTCCCGGTA
CAAGGATTGGCTGACCATCCACCGGGTGTGGCGCAGCGCATTGCCCGACGAGATCGAGAAGGGCTCGGTCGTCGAGTCGA
TCGTCGAGGTCAAGGGCATGCCCAACCGGATCAAATGGACGGTCGTGCGCTACAAGCCACCCGAGGGCATGACGCTCAAC
GGCGACGGAGTCGGCGGGGTCAAGGTCAAGCTGATGGCCAAGATCCAGCCCAAAGGGGACGGCTCCCTCGTCAGTTTCGA
CGTGCACCTCGGTGGCCCCGCGCTGTTCGGCCCCATCGGCATGATCGTCGCCGCCGCGCTGCGCGGCGATATCGACCAGT
CGCTGGAGAACTTCGTGGCGGTGTTCACCCGGCCCGATCCGAGCAGCAACGGGCATCGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9996.46 Da        Isoelectric Point: 10.1757

>AT169301 WP_002887278.1 NZ_CP059889:c4723047-4722781 [Klebsiella pneumoniae subsp. pneumoniae]
MPALKKQRIDLRLTDDDKSIIEEAAAISNQTITQFVVASASERAAEVIEQHRRMVLNEQSWSLVMEAITQPPAPNDRLKR
AAKRLQTR

Download         Length: 267 bp

>AT169301 NZ_CP076382:887542-887730 [Mycobacterium intracellulare ATCC 13950]
ATGGGATTCCTGGACAAGGCCAAGGATCTGTTGTCGCAGAACGCCGACAAGGTCGAGACGGCCATCGACAAGGCAGGCGA
GTTCGTCGACGAAAAGACGCAGGGCAAATACTCCGACACCATTCACCAGGTGCAGGAGCAGGCGAAGAAGGCGGCCGGCG
CCGCGGACACGGGCGACCAGCAGAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A060VJ83

Antitoxin

Source ID Structure
PDB 5ZGN
AlphaFold DB A0A0H3GLZ1

References