Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 850977..851634 Replicon chromosome
Accession NZ_CP059889
Organism Klebsiella pneumoniae subsp. pneumoniae strain KP18069

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag H4N62_RS04225 Protein ID WP_002916310.1
Coordinates 851224..851634 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag H4N62_RS04220 Protein ID WP_002916312.1
Coordinates 850977..851243 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H4N62_RS04195 846133..847566 - 1434 WP_004185559.1 6-phospho-beta-glucosidase BglA -
H4N62_RS04200 847685..848413 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
H4N62_RS04205 848463..848774 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
H4N62_RS04210 848938..849597 + 660 WP_002916317.1 hemolysin III family protein -
H4N62_RS04215 849748..850731 - 984 WP_020324927.1 tRNA-modifying protein YgfZ -
H4N62_RS04220 850977..851243 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
H4N62_RS04225 851224..851634 + 411 WP_002916310.1 protein YgfX Toxin
H4N62_RS04230 851641..852162 - 522 WP_004144730.1 flavodoxin FldB -
H4N62_RS04235 852263..853159 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
H4N62_RS04240 853182..853895 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
H4N62_RS04245 853901..855634 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T169289 WP_002916310.1 NZ_CP059889:851224-851634 [Klebsiella pneumoniae subsp. pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T169289 NZ_CP076378:c4575335-4574874 [Mycobacterium intracellulare]
ATGGCCAAGCTTTCCGGATCCATCGATGTCCCGCTGCCGCCCGAGGTGGCCTGGCAGCACGCCTCCGACCTGTCCCGGTA
CAAGGATTGGCTGACCATCCACCGGGTGTGGCGCAGCGCATTGCCCGACGAGATCGAGAAGGGCTCGGTCGTCGAGTCGA
TTGTCGAGGTCAAGGGCATGCCCAACCGGATCAAATGGACGGTCGTGCGCTACAAGCCACCCGAGGGCATGACGCTCAAC
GGCGACGGAGTCGGCGGGGTCAAGGTCAAGCTGATGGCCAAGATCCAGCCCAAAGGGGACGGCTCCCTCGTCAGTTTCGA
CGTGCACCTCGGTGGCCCCGCACTGTTCGGCCCCATCGGCATGATCGTCGCCGCCGCACTGCGCGGCGATATCGACCAGT
CGCTGGAGAACTTCGTGACGGTGTTCACCCGGCCCGATCCGAGCAGCAACGGGCATCGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT169289 WP_002916312.1 NZ_CP059889:850977-851243 [Klebsiella pneumoniae subsp. pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT169289 NZ_CP076378:c4575527-4575339 [Mycobacterium intracellulare]
ATGGGATTCCTGGACAAGGCCAAGGATCTGTTGTCGCAGAACGCCGACAAGGTCGAGACGGCCATCGACAAGGCAGGCGA
GTTCGTCGACGAAAAGACGCAGGGCAAATACTCCGACACCATTCACCAGGTGCAGGAGCAGGCGAAGAAGGCGGCGGGCG
CCGCGGACACGGGCGACCAGCAGAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References