Detailed information of TA system TA169283

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yoeB-relB/YoeB-YefM
• Location: 3567210..3567716
• Replicon: chromosome
• Accession: NZ_CP059853
• Organism: Glutamicibacter nicotianae strain ZM05

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: H3Z72_RS16870
• Protein ID: WP_128470932.1
• Coordinates: 3567462..3567716 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A4Y3VX22
• Locus tag: H3Z72_RS16865
• Protein ID: WP_038992858.1
• Coordinates: 3567210..3567461 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H3Z72_RS16850	3563015..3564802	-	1788	WP_190264299.1	plasmid pRiA4b ORF-3 family protein	-
H3Z72_RS16855	3565006..3565704	+	699	WP_190264300.1	maleylpyruvate isomerase family mycothiol-dependent enzyme	-
H3Z72_RS16860	3565798..3566853	+	1056	WP_190264301.1	GTP-binding protein	-
H3Z72_RS16865	3567210..3567461	+	252	WP_038992858.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
H3Z72_RS16870	3567462..3567716	+	255	WP_128470932.1	Txe/YoeB family addiction module toxin	Toxin
H3Z72_RS16875	3567712..3567939	+	228	WP_190265252.1	hypothetical protein	-
H3Z72_RS16880	3569068..3569904	-	837	WP_038992854.1	(S)-ureidoglycine aminohydrolase	-
H3Z72_RS16885	3569915..3571168	-	1254	WP_190264302.1	aldolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (2-69)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9996.39 Da
• Isoelectric Point: 7.2749

>T169283 WP_128470932.1 NZ_CP059853:3567462-3567716 [Glutamicibacter nicotianae]
VRLVWDRAGWDDYVHWQTADRRVLKRVNTLIEACLPDPFQGIGKPEQLKYGASGSWSRRITDEHRLVYIVIEEDLIILQA
RYHY

Nucleotide

• Length: 255 bp

>T169283 NZ_CP076364:c4979-4728 [Gemmobacter fulva]
ATGAAGCAGATCAGTTACACGAAGGCCGCGATCAGGGCGTTGCGCCGGATGCCGGCAAACACGGCCGTGCTGATCCGTTC
CAAGATCGAGGCCTACGCACAGGACCCGGCCTCACAGGGCAACAACCTGAGGGCCCTCAAGGGGCGTGAGGGGATCCGTC
TGCGGGTTGGTGACTGGCGTGTGGTCATGGATGACCAGGGCAATGTCCTCGCAGTTCTCGATATAGGGCCACGCGGCGGC
ATCTATGACTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9459.51 Da
• Isoelectric Point: 4.4805

>AT169283 WP_038992858.1 NZ_CP059853:3567210-3567461 [Glutamicibacter nicotianae]
MSISASEARKTLFPLIEQVNDDRQAVEIVSRKGNAVLMAADEYAAWQETAYLFRSPANARRLLDAYERARSGITETHELD
WDE

Nucleotide

• Length: 252 bp

>AT169283 NZ_CP076364:c4716-4372 [Gemmobacter fulva]
ATGAACGAGATGGTGACGATCCCCCGCGAAGAATATGACCGCCTGCGGGCCGCGGCCGAAGATCTGGCCGATCTGCAGAG
CTATGATCGGGCAAAGGCGGCCCTGGGAGCGGGCGGAGATGAACTGATTCCCTCCGACTACGCGAACCGGTTACTCGACG
GAGAAAACCCGCTGCGCGTCTACCGAGACCTGCGCGGCCTGACCCAAGCCACACTGGCCGAAAGGGCCGACGTCAACCGC
GTCACTGTGGCGGAGATCGAGACGGGCCGCAAACAGGGCTCGATCGCAACCTTGCGCGCGCTGGCGGGCGCTCTCGACAT
CACTCTGGACGATCTGACGGAGTAG

Structures

Antitoxin

• AlphaFold DB: A0A4Y3VX22