169282

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pasABC/RelE-HTH
Location 3235756..3236233 Replicon chromosome
Accession NZ_CP059851
Organism Sandaracinobacter sp. M6

Toxin (Protein)


Gene name pasB Uniprot ID -
Locus tag H3309_RS16220 Protein ID WP_182296081.1
Coordinates 3235756..3236028 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name pasA Uniprot ID -
Locus tag H3309_RS16225 Protein ID WP_182298864.1
Coordinates 3236012..3236233 (-) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H3309_RS16190 3231209..3231991 + 783 WP_182296069.1 uroporphyrinogen-III C-methyltransferase -
H3309_RS16195 3231988..3232269 + 282 WP_182296071.1 DUF2849 domain-containing protein -
H3309_RS16200 3232269..3233891 + 1623 WP_182296073.1 nitrite/sulfite reductase -
H3309_RS16205 3233884..3234276 + 393 WP_182296075.1 DUF934 domain-containing protein -
H3309_RS16210 3234269..3234991 + 723 WP_182296077.1 phosphoadenylyl-sulfate reductase -
H3309_RS16215 3235024..3235698 + 675 WP_182296079.1 hypothetical protein -
H3309_RS16220 3235756..3236028 - 273 WP_182296081.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H3309_RS16225 3236012..3236233 - 222 WP_182298864.1 CopG family transcriptional regulator Antitoxin
H3309_RS16230 3236432..3236635 + 204 WP_182296083.1 50S ribosomal protein L35 -
H3309_RS16235 3236650..3237015 + 366 WP_182296085.1 50S ribosomal protein L20 -
H3309_RS16240 3237106..3238365 + 1260 WP_182296087.1 type VI secretion protein ImpB -
H3309_RS16245 3238402..3240561 + 2160 WP_182296089.1 phosphoribosylformylglycinamidine synthase subunit PurL -
H3309_RS16250 3240545..3241090 - 546 WP_182298866.1 peroxiredoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-88)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10740.39 Da        Isoelectric Point: 10.6412

>T169282 WP_182296081.1 NZ_CP059851:c3236028-3235756 [Sandaracinobacter sp. M6]
MAWRIEFAASAEKQLRKLDPQIARRILTFLRDRVAALDDPRSIGEALRGREWGDFWKYRVGDWRIIADIEDEVVLITVVR
LGNRREVYRR

Download         Length: 273 bp

>T169282 NZ_CP076346:c27023-26742 [Escherichia coli]
ATGACCTATGAACTGGCTTTTGATCGCAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAGCTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATATCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCTGTTGGAAGA
AGGGAAAGCAGCGAAGTTTATCAGATTGCAGATATGCGCTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7849.86 Da        Isoelectric Point: 4.5515

>AT169282 WP_182298864.1 NZ_CP059851:c3236233-3236012 [Sandaracinobacter sp. M6]
MSLRLPAPIEDRLSALAALTGRSKTFYATEAIVEHIDDLEDAHLSAAVRARVRAGAEGRVALSELLEDYGLAD

Download         Length: 222 bp

>AT169282 NZ_CP076346:c27264-27013 [Escherichia coli]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References