Detailed information of TA system TA169281

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 3177637..3178310
• Replicon: chromosome
• Accession: NZ_CP059851
• Organism: Sandaracinobacter sp. M6

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: H3309_RS15935
• Protein ID: WP_182295976.1
• Coordinates: 3177637..3178041 (-)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: H3309_RS15940
• Protein ID: WP_182295977.1
• Coordinates: 3178038..3178310 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H3309_RS15915	3173299..3173763	-	465	WP_182295970.1	DUF1772 domain-containing protein	-
H3309_RS15920	3173897..3174022	-	126	Protein_3140	PEPxxWA-CTERM sorting domain-containing protein	-
H3309_RS15925	3174768..3176132	+	1365	WP_182295972.1	alpha/beta hydrolase	-
H3309_RS15930	3176246..3177640	-	1395	WP_182295974.1	dihydrolipoyl dehydrogenase	-
H3309_RS15935	3177637..3178041	-	405	WP_182295976.1	type II toxin-antitoxin system VapC family toxin	Toxin
H3309_RS15940	3178038..3178310	-	273	WP_182295977.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
H3309_RS15945	3178361..3179626	-	1266	WP_182298858.1	2-oxoglutarate dehydrogenase complex dihydrolipoyllysine-residue succinyltransferase	-
H3309_RS15950	3179637..3182465	-	2829	WP_182295979.1	2-oxoglutarate dehydrogenase E1 component	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-124)

Antitoxin

• Antitoxin VapB-like (5-89)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 14314.50 Da
• Isoelectric Point: 5.7034

>T169281 WP_182295976.1 NZ_CP059851:c3178041-3177637 [Sandaracinobacter sp. M6]
MIVDTSALLAIIYGEPEAESFARLILAESTPAMAAVTYLEAALKLDGDLKKPLGPRLDDTIAMLGLGTLSFTAEHARLAR
QAAKQFGKGNHPAKLNFGDCIVYATAQLANRPLLFKGNDFSQTDLVPAISKDNP

Nucleotide

• Length: 405 bp

>T169281 NZ_CP076345:94079-94495 [Escherichia coli]
GTGAACAAGATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAACCTGAAGCATTGCTTAAGCACCT
GGAGCAGTCGGTGCTGCGCGGTCACCGTATCGTGGTCTCGGCCATCACCTACTCCGAGATGCGCTTCGGTGCCACCGGTC
CGAAGGCCTCGCCACGCCACGTGCAACTGGTTGACGCGTTCTGTGAGAGGCTCGATGCCGTCCTGCCGTGGGACCGCGCC
GCGGTGGATGCGACCACGGAGATTAAGGTGGCACTGCGTCTCGCCGGCACGCCGATCGGTCCGAACGACACGGCGATAGC
CGGACACGCCATCGCTGCCTGTGCCATTCTGGTGACGAATAATGTGAGAGAGTTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10021.32 Da
• Isoelectric Point: 5.1239

>AT169281 WP_182295977.1 NZ_CP059851:c3178310-3178038 [Sandaracinobacter sp. M6]
VGRQLNIKHDDAWALAERLSRKTGESMTDAVVVSLRERLARLEGARQAEVEAKLAALRAMASSIQADLRPDAMTAEQFDA
WMYDDQGLPH

Nucleotide

• Length: 273 bp

>AT169281 NZ_CP076345:93852-94082 [Escherichia coli]
ATGAGAACCGTATCCATTTTTAAAAATGGCAACAACCGTGCTATCCGCCTTCCACGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGCCCCGTCCGGCCGACCTGGGGCTCATTCCTGGAGCTAG
AAAAGGCCGATCCGGACTTTATGACGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGAGTTAACCTGTGA