Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3170418..3171019 Replicon chromosome
Accession NZ_CP059851
Organism Sandaracinobacter sp. M6

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag H3309_RS15895 Protein ID WP_207791529.1
Coordinates 3170418..3170621 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag H3309_RS15900 Protein ID WP_182295964.1
Coordinates 3170621..3171019 (+) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H3309_RS15865 3166194..3166628 + 435 WP_182295952.1 DNA polymerase III subunit chi -
H3309_RS15870 3166710..3167132 + 423 WP_182295954.1 nucleoside-diphosphate kinase -
H3309_RS15875 3167122..3167490 - 369 WP_182295956.1 hypothetical protein -
H3309_RS15880 3167568..3168488 + 921 WP_182295958.1 SMP-30/gluconolactonase/LRE family protein -
H3309_RS15885 3168564..3169460 - 897 WP_182295960.1 hypothetical protein -
H3309_RS15890 3169520..3170398 + 879 WP_182295962.1 tyrosine recombinase -
H3309_RS15895 3170418..3170621 + 204 WP_207791529.1 type II toxin-antitoxin system HicA family toxin Toxin
H3309_RS15900 3170621..3171019 + 399 WP_182295964.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
H3309_RS15905 3171024..3171941 - 918 WP_182295966.1 cysteine synthase A -
H3309_RS15910 3171994..3173259 - 1266 WP_182295968.1 MFS transporter -
H3309_RS15915 3173299..3173763 - 465 WP_182295970.1 DUF1772 domain-containing protein -
H3309_RS15920 3173897..3174022 - 126 Protein_3140 PEPxxWA-CTERM sorting domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(8-63)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 7540.87 Da        Isoelectric Point: 11.9500

>T169280 WP_207791529.1 NZ_CP059851:3170418-3170621 [Sandaracinobacter sp. M6]
MMRTVRSSDLIAELCAEGWILDRVRGSHHVFRHPTRAGITVVPHPKKDLGVGLVAAIRRQAGMRKER

Download         Length: 204 bp

>T169280 NZ_CP059851:3170418-3170621 [Sandaracinobacter sp. M6]
ATGATGCGCACTGTGAGAAGTTCCGACCTGATCGCTGAGTTATGTGCGGAAGGTTGGATTTTGGATCGGGTGCGGGGCTC
GCACCATGTGTTCCGTCATCCGACGCGAGCGGGCATCACGGTTGTGCCCCATCCGAAGAAAGATCTGGGCGTCGGGCTTG
TGGCCGCCATCCGACGCCAGGCCGGCATGAGGAAGGAGAGGTGA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 13763.51 Da        Isoelectric Point: 4.1349

>AT169280 WP_182295964.1 NZ_CP059851:3170621-3171019 [Sandaracinobacter sp. M6]
MRYPIAIEPATAGTAYGVVIPDLPGAFSAGDTLDEAMAGAEEAAAAWIDATLDAGGAIPEPSSLEAVRDDPAFAGWSFGV
ITLDPALLDDAIERINVTLPRRVLRRLDSMARSAGASRSGYIARMTLSDRTA

Download         Length: 399 bp

>AT169280 NZ_CP059851:3170621-3171019 [Sandaracinobacter sp. M6]
ATGCGCTATCCGATCGCGATCGAGCCGGCAACGGCCGGCACTGCCTATGGGGTGGTCATTCCGGACCTGCCGGGGGCTTT
TTCAGCGGGAGACACGCTTGATGAGGCCATGGCAGGCGCGGAGGAGGCCGCGGCTGCCTGGATCGACGCGACCCTGGATG
CCGGGGGTGCCATTCCTGAGCCTTCCAGCCTGGAAGCCGTTCGCGATGATCCCGCCTTTGCGGGATGGAGTTTCGGCGTG
ATCACGCTCGATCCGGCGCTGCTTGACGATGCCATCGAACGGATCAACGTCACGCTGCCACGCCGGGTGTTGCGGCGTCT
GGACAGCATGGCCCGGTCGGCCGGCGCGAGCCGGTCCGGGTATATCGCGCGCATGACGCTGTCCGACCGGACGGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References