Detailed information of TA system TA169280

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 3170418..3171019
• Replicon: chromosome
• Accession: NZ_CP059851
• Organism: Sandaracinobacter sp. M6

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: H3309_RS15895
• Protein ID: WP_207791529.1
• Coordinates: 3170418..3170621 (+)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: H3309_RS15900
• Protein ID: WP_182295964.1
• Coordinates: 3170621..3171019 (+)
• Length: 133 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H3309_RS15865	3166194..3166628	+	435	WP_182295952.1	DNA polymerase III subunit chi	-
H3309_RS15870	3166710..3167132	+	423	WP_182295954.1	nucleoside-diphosphate kinase	-
H3309_RS15875	3167122..3167490	-	369	WP_182295956.1	hypothetical protein	-
H3309_RS15880	3167568..3168488	+	921	WP_182295958.1	SMP-30/gluconolactonase/LRE family protein	-
H3309_RS15885	3168564..3169460	-	897	WP_182295960.1	hypothetical protein	-
H3309_RS15890	3169520..3170398	+	879	WP_182295962.1	tyrosine recombinase	-
H3309_RS15895	3170418..3170621	+	204	WP_207791529.1	type II toxin-antitoxin system HicA family toxin	Toxin
H3309_RS15900	3170621..3171019	+	399	WP_182295964.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
H3309_RS15905	3171024..3171941	-	918	WP_182295966.1	cysteine synthase A	-
H3309_RS15910	3171994..3173259	-	1266	WP_182295968.1	MFS transporter	-
H3309_RS15915	3173299..3173763	-	465	WP_182295970.1	DUF1772 domain-containing protein	-
H3309_RS15920	3173897..3174022	-	126	Protein_3140	PEPxxWA-CTERM sorting domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (8-63)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 7540.87 Da
• Isoelectric Point: 11.9500

>T169280 WP_207791529.1 NZ_CP059851:3170418-3170621 [Sandaracinobacter sp. M6]
MMRTVRSSDLIAELCAEGWILDRVRGSHHVFRHPTRAGITVVPHPKKDLGVGLVAAIRRQAGMRKER

Nucleotide

• Length: 204 bp

>T169280 NZ_CP059851:3170418-3170621 [Sandaracinobacter sp. M6]
ATGATGCGCACTGTGAGAAGTTCCGACCTGATCGCTGAGTTATGTGCGGAAGGTTGGATTTTGGATCGGGTGCGGGGCTC
GCACCATGTGTTCCGTCATCCGACGCGAGCGGGCATCACGGTTGTGCCCCATCCGAAGAAAGATCTGGGCGTCGGGCTTG
TGGCCGCCATCCGACGCCAGGCCGGCATGAGGAAGGAGAGGTGA

Antitoxin

Protein

• Length: 133 a.a.
• Molecular weight: 13763.51 Da
• Isoelectric Point: 4.1349

>AT169280 WP_182295964.1 NZ_CP059851:3170621-3171019 [Sandaracinobacter sp. M6]
MRYPIAIEPATAGTAYGVVIPDLPGAFSAGDTLDEAMAGAEEAAAAWIDATLDAGGAIPEPSSLEAVRDDPAFAGWSFGV
ITLDPALLDDAIERINVTLPRRVLRRLDSMARSAGASRSGYIARMTLSDRTA

Nucleotide

• Length: 399 bp

>AT169280 NZ_CP059851:3170621-3171019 [Sandaracinobacter sp. M6]
ATGCGCTATCCGATCGCGATCGAGCCGGCAACGGCCGGCACTGCCTATGGGGTGGTCATTCCGGACCTGCCGGGGGCTTT
TTCAGCGGGAGACACGCTTGATGAGGCCATGGCAGGCGCGGAGGAGGCCGCGGCTGCCTGGATCGACGCGACCCTGGATG
CCGGGGGTGCCATTCCTGAGCCTTCCAGCCTGGAAGCCGTTCGCGATGATCCCGCCTTTGCGGGATGGAGTTTCGGCGTG
ATCACGCTCGATCCGGCGCTGCTTGACGATGCCATCGAACGGATCAACGTCACGCTGCCACGCCGGGTGTTGCGGCGTCT
GGACAGCATGGCCCGGTCGGCCGGCGCGAGCCGGTCCGGGTATATCGCGCGCATGACGCTGTCCGACCGGACGGCTTGA