Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 3105629..3106203 Replicon chromosome
Accession NZ_CP059851
Organism Sandaracinobacter sp. M6

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag H3309_RS15585 Protein ID WP_182295847.1
Coordinates 3105913..3106203 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag H3309_RS15580 Protein ID WP_182295844.1
Coordinates 3105629..3105910 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H3309_RS15560 3100997..3101779 - 783 WP_182295834.1 phenylalanine 4-monooxygenase -
H3309_RS15565 3101941..3103008 + 1068 WP_182295836.1 Ppx/GppA family phosphatase -
H3309_RS15570 3103005..3103727 + 723 WP_182295839.1 RlmE family RNA methyltransferase -
H3309_RS15575 3103984..3105369 - 1386 WP_182295842.1 hypothetical protein -
H3309_RS15580 3105629..3105910 - 282 WP_182295844.1 putative addiction module antidote protein Antitoxin
H3309_RS15585 3105913..3106203 - 291 WP_182295847.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H3309_RS15590 3106474..3107862 - 1389 WP_182295850.1 DUF2252 domain-containing protein -
H3309_RS15595 3107865..3108479 - 615 WP_182295852.1 glutathione S-transferase family protein -
H3309_RS15600 3108557..3109900 + 1344 WP_207791526.1 MFS transporter -
H3309_RS15605 3109931..3110995 - 1065 WP_182295856.1 DUF1624 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3086302..3109900 23598


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-95)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-90)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10664.36 Da        Isoelectric Point: 10.4469

>T169279 WP_182295847.1 NZ_CP059851:c3106203-3105913 [Sandaracinobacter sp. M6]
MFEVRRTGAFIDWLTGLKDVQGRARIAKRLDRLVDGNFGDAKSVGGGVSELRFTFGPGYRVYFTVRGQVVVILLCGGDKQ
SQVRDIDRAILMAKEV

Download         Length: 291 bp

>T169279 NZ_CP076345:c84805-84500 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10060.58 Da        Isoelectric Point: 5.1088

>AT169279 WP_182295844.1 NZ_CP059851:c3105910-3105629 [Sandaracinobacter sp. M6]
MAIETKPWDAAEVLNTPADIAAYLDAYLEDGTPEELLRAVKAIARSRGMSELARQSGISREALYRAFGDKGNPTLDTLLR
VMKALGVRLAIAA

Download         Length: 282 bp

>AT169279 NZ_CP076345:c85025-84807 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References