Detailed information of TA system TA169279

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PumAB/upstrm_HI1419-dnstrm_HI1420
• Location: 3105629..3106203
• Replicon: chromosome
• Accession: NZ_CP059851
• Organism: Sandaracinobacter sp. M6

Toxin (Protein)

• Gene name: PumA
• Uniprot ID: -
• Locus tag: H3309_RS15585
• Protein ID: WP_182295847.1
• Coordinates: 3105913..3106203 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: -
• Locus tag: H3309_RS15580
• Protein ID: WP_182295844.1
• Coordinates: 3105629..3105910 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H3309_RS15560	3100997..3101779	-	783	WP_182295834.1	phenylalanine 4-monooxygenase	-
H3309_RS15565	3101941..3103008	+	1068	WP_182295836.1	Ppx/GppA family phosphatase	-
H3309_RS15570	3103005..3103727	+	723	WP_182295839.1	RlmE family RNA methyltransferase	-
H3309_RS15575	3103984..3105369	-	1386	WP_182295842.1	hypothetical protein	-
H3309_RS15580	3105629..3105910	-	282	WP_182295844.1	putative addiction module antidote protein	Antitoxin
H3309_RS15585	3105913..3106203	-	291	WP_182295847.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H3309_RS15590	3106474..3107862	-	1389	WP_182295850.1	DUF2252 domain-containing protein	-
H3309_RS15595	3107865..3108479	-	615	WP_182295852.1	glutathione S-transferase family protein	-
H3309_RS15600	3108557..3109900	+	1344	WP_207791526.1	MFS transporter	-
H3309_RS15605	3109931..3110995	-	1065	WP_182295856.1	DUF1624 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3086302..3109900	23598

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Addiction module killer protein, predicted (3-95)

Antitoxin

• Cro/C1-type helix-turn-helix domain (38-90)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10664.36 Da
• Isoelectric Point: 10.4469

>T169279 WP_182295847.1 NZ_CP059851:c3106203-3105913 [Sandaracinobacter sp. M6]
MFEVRRTGAFIDWLTGLKDVQGRARIAKRLDRLVDGNFGDAKSVGGGVSELRFTFGPGYRVYFTVRGQVVVILLCGGDKQ
SQVRDIDRAILMAKEV

Nucleotide

• Length: 291 bp

>T169279 NZ_CP076345:c84805-84500 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10060.58 Da
• Isoelectric Point: 5.1088

>AT169279 WP_182295844.1 NZ_CP059851:c3105910-3105629 [Sandaracinobacter sp. M6]
MAIETKPWDAAEVLNTPADIAAYLDAYLEDGTPEELLRAVKAIARSRGMSELARQSGISREALYRAFGDKGNPTLDTLLR
VMKALGVRLAIAA

Nucleotide

• Length: 282 bp

>AT169279 NZ_CP076345:c85025-84807 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA