Detailed information of TA system TA169278

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-PumB/upstrm_HI1419-DUF971
• Location: 3098901..3099547
• Replicon: chromosome
• Accession: NZ_CP059851
• Organism: Sandaracinobacter sp. M6

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: H3309_RS15540
• Protein ID: WP_182295829.1
• Coordinates: 3098901..3099242 (+)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: -
• Locus tag: H3309_RS15545
• Protein ID: WP_207791525.1
• Coordinates: 3099239..3099547 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H3309_RS15520	3095277..3096356	+	1080	WP_182295822.1	ionic transporter y4hA	-
H3309_RS15525	3096455..3096595	-	141	WP_182295824.1	hypothetical protein	-
H3309_RS15530	3096705..3098612	+	1908	WP_182295826.1	TonB-dependent receptor	-
H3309_RS15540	3098901..3099242	+	342	WP_182295829.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H3309_RS15545	3099239..3099547	+	309	WP_207791525.1	putative addiction module antidote protein	Antitoxin
H3309_RS15550	3099628..3100296	+	669	WP_182295831.1	hypothetical protein	-
H3309_RS15555	3100628..3100981	+	354	WP_182298849.1	GFA family protein	-
H3309_RS15560	3100997..3101779	-	783	WP_182295834.1	phenylalanine 4-monooxygenase	-
H3309_RS15565	3101941..3103008	+	1068	WP_182295836.1	Ppx/GppA family phosphatase	-
H3309_RS15570	3103005..3103727	+	723	WP_182295839.1	RlmE family RNA methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3086302..3109900	23598

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (13-92)

Antitoxin

• Cro/C1-type helix-turn-helix domain (51-92)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 13001.97 Da
• Isoelectric Point: 9.9921

>T169278 WP_182295829.1 NZ_CP059851:3098901-3099242 [Sandaracinobacter sp. M6]
MYIIERTVVFDGWLDGLKDRTAQKRVAMRLTRIESGLLGDWKTLGDGISELRIDHGPGYRIYFTRRDQRIIILLCGSDKG
DQDRAIRQARQMAKDLDIPLMTSPRPQRPGTTE

Nucleotide

• Length: 342 bp

>T169278 NZ_CP076344:4916741-4917052 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGAACGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTCTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 10842.49 Da
• Isoelectric Point: 5.0335

>AT169278 WP_207791525.1 NZ_CP059851:3099239-3099547 [Sandaracinobacter sp. M6]
VTMTQLATTPFDAAKYITEPADVVDFLNDAFDSGHAPYIAKVLGIVARSEGMSKIADKTGVNRQALYTALSEQGNPTLET
LLKVLSALGMKLKCEPDLAKAA

Nucleotide

• Length: 309 bp

>AT169278 NZ_CP076344:4917053-4917343 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
ACGTACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG