Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 2989479..2990026 Replicon chromosome
Accession NZ_CP059851
Organism Sandaracinobacter sp. M6

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag H3309_RS14990 Protein ID WP_182295638.1
Coordinates 2989736..2990026 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag H3309_RS14985 Protein ID WP_207791522.1
Coordinates 2989479..2989739 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H3309_RS14950 2984658..2984867 + 210 WP_182295628.1 LPXTG cell wall anchor domain-containing protein -
H3309_RS14955 2984862..2985176 - 315 WP_182295630.1 antibiotic biosynthesis monooxygenase -
H3309_RS14960 2985173..2985712 - 540 WP_182295632.1 nucleotide exchange factor GrpE -
H3309_RS14965 2985709..2986734 - 1026 WP_182298823.1 heat-inducible transcriptional repressor HrcA -
H3309_RS14970 2986842..2987558 + 717 WP_182295634.1 ribonuclease PH -
H3309_RS14975 2987575..2988177 + 603 WP_182298825.1 non-canonical purine NTP pyrophosphatase -
H3309_RS14980 2988288..2989439 + 1152 WP_182295636.1 coproporphyrinogen III oxidase -
H3309_RS14985 2989479..2989739 + 261 WP_207791522.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
H3309_RS14990 2989736..2990026 + 291 WP_182295638.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H3309_RS14995 2990117..2990821 + 705 WP_182295640.1 pirin family protein -
H3309_RS15000 2990890..2991174 + 285 WP_182295642.1 hypothetical protein -
H3309_RS15005 2991104..2991520 - 417 WP_182295644.1 DUF4345 domain-containing protein -
H3309_RS15010 2991517..2992524 - 1008 WP_182298829.1 NADP-dependent oxidoreductase -
H3309_RS15015 2992588..2993226 - 639 WP_182295646.1 TIGR02117 family protein -
H3309_RS15020 2993226..2994083 - 858 WP_182295647.1 alpha/beta hydrolase -
H3309_RS15025 2994201..2994854 + 654 WP_182295649.1 TetR/AcrR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-91)

Antitoxin

Antitoxin ParD

(10-84)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10720.12 Da        Isoelectric Point: 8.4951

>T169277 WP_182295638.1 NZ_CP059851:2989736-2990026 [Sandaracinobacter sp. M6]
MSSALYSNRAVDDLRTIETYTATQWGDAQADRYVRAIMTAVDRLAENPALGRAVAVNFGQYRRISSGSHVIYVVVQDGQT
TVVRILHQRMEPGLHL

Download         Length: 291 bp

>T169277 NZ_CP076344:4063889-4064353 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGTTCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9382.57 Da        Isoelectric Point: 4.8177

>AT169277 WP_207791522.1 NZ_CP059851:2989479-2989739 [Sandaracinobacter sp. M6]
MVAIAPARTLTMKLGPYFDRLIEGQIASGRYGSVDDVIREALTRLQDHETRVEALGEALREGEESGLHGPLDANAFLQEC
RAARSA

Download         Length: 261 bp

>AT169277 NZ_CP076344:4063554-4063889 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References