Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 2750558..2751138 Replicon chromosome
Accession NZ_CP059851
Organism Sandaracinobacter sp. M6

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag H3309_RS13845 Protein ID WP_182295290.1
Coordinates 2750558..2750851 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag H3309_RS13850 Protein ID WP_182295292.1
Coordinates 2750851..2751138 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H3309_RS13830 2746210..2747859 - 1650 WP_182295284.1 electron transfer flavoprotein-ubiquinone oxidoreductase -
H3309_RS13835 2747976..2748689 + 714 WP_182295286.1 uracil-DNA glycosylase -
H3309_RS13840 2748686..2750527 + 1842 WP_182295288.1 lytic transglycosylase domain-containing protein -
H3309_RS13845 2750558..2750851 + 294 WP_182295290.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H3309_RS13850 2750851..2751138 + 288 WP_182295292.1 putative addiction module antidote protein Antitoxin
H3309_RS13855 2751138..2751665 + 528 WP_182295294.1 molybdenum cofactor biosynthesis protein B -
H3309_RS13860 2751686..2752684 + 999 WP_182295296.1 magnesium transporter CorA family protein -
H3309_RS13865 2752721..2755870 - 3150 WP_182295298.1 TonB-dependent receptor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-96)

Antitoxin

Uncharacterized protein HI1420

(9-94)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11090.91 Da        Isoelectric Point: 10.5109

>T169275 WP_182295290.1 NZ_CP059851:2750558-2750851 [Sandaracinobacter sp. M6]
VIDVKQTRIFADWLRDLRDARARDRIELRLARIAVGHFGDVKRVGRKLIEARVDYGPGYRVYLVRRGQKLVVLLCGGDKS
SQQRDIAAALAMIEELD

Download         Length: 294 bp

>T169275 NZ_CP076344:c3956432-3956136 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 9824.36 Da        Isoelectric Point: 6.2415

>AT169275 WP_182295292.1 NZ_CP059851:2750851-2751138 [Sandaracinobacter sp. M6]
MPLDLLPYDASACLVGRPEEQASLLSDALATNDPDIVAGALALIARAQGVSAMARETGLSREAIYKATRKDGNPRLSTLI
AMLKSAGIKLTATAA

Download         Length: 288 bp

>AT169275 NZ_CP076344:c3956134-3955739 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References