Detailed information of TA system TA169273

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 2074175..2074697
• Replicon: chromosome
• Accession: NZ_CP059851
• Organism: Sandaracinobacter sp. M6

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: H3309_RS10445
• Protein ID: WP_182294660.1
• Coordinates: 2074410..2074697 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: H3309_RS10440
• Protein ID: WP_182294659.1
• Coordinates: 2074175..2074423 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H3309_RS10415	2069362..2069631	-	270	WP_182294654.1	hypothetical protein	-
H3309_RS10420	2069980..2071242	+	1263	WP_182294655.1	UbiH/UbiF/VisC/COQ6 family ubiquinone biosynthesis hydroxylase	-
H3309_RS10425	2071291..2072778	+	1488	WP_182294656.1	AbgT family transporter	-
H3309_RS10430	2072781..2073566	-	786	WP_182294657.1	succinate dehydrogenase iron-sulfur subunit	-
H3309_RS10435	2073766..2074044	-	279	WP_182294658.1	DUF1902 domain-containing protein	-
H3309_RS10440	2074175..2074423	+	249	WP_182294659.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
H3309_RS10445	2074410..2074697	+	288	WP_182294660.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
H3309_RS10450	2074739..2075224	-	486	WP_182294661.1	hypothetical protein	-
H3309_RS10455	2075234..2077021	-	1788	WP_182294662.1	succinate dehydrogenase flavoprotein subunit	-
H3309_RS10460	2077023..2077403	-	381	WP_182294663.1	succinate dehydrogenase, hydrophobic membrane anchor protein	-
H3309_RS10465	2077403..2077804	-	402	WP_182294664.1	succinate dehydrogenase, cytochrome b556 subunit	-
H3309_RS10470	2078105..2078575	-	471	WP_182294665.1	DUF1330 domain-containing protein	-
H3309_RS10475	2078559..2078912	-	354	WP_182294666.1	protein kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (10-77)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11026.92 Da
• Isoelectric Point: 10.9353

>T169273 WP_182294660.1 NZ_CP059851:2074410-2074697 [Sandaracinobacter sp. M6]
MTTYRLTFLRDAKKEWDKLDSKIRNQFSKKLAERLSNPRIPSAKLAGMPNCYKIKLHSAGYRLVYRVDDGRIVVQVIAVG
KRERSAIYEAANKRI

Nucleotide

• Length: 288 bp

>T169273 NZ_CP076344:c3593205-3592870 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATACGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTCTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGA
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8738.97 Da
• Isoelectric Point: 3.8345

>AT169273 WP_182294659.1 NZ_CP059851:2074175-2074423 [Sandaracinobacter sp. M6]
MIEPLLASAAVSISNLKKNPSAVIAAAEGAPVAILNRNTPQAYLVPAAAWEALMDQLEDLELAAIVREREGQEEIEVSID
DL

Nucleotide

• Length: 249 bp

>AT169273 NZ_CP076344:c3593453-3593205 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGGGAGCCGAAAGATAAGGAA
GTCTGGTAA