Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 2074175..2074697 Replicon chromosome
Accession NZ_CP059851
Organism Sandaracinobacter sp. M6

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag H3309_RS10445 Protein ID WP_182294660.1
Coordinates 2074410..2074697 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag H3309_RS10440 Protein ID WP_182294659.1
Coordinates 2074175..2074423 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H3309_RS10415 2069362..2069631 - 270 WP_182294654.1 hypothetical protein -
H3309_RS10420 2069980..2071242 + 1263 WP_182294655.1 UbiH/UbiF/VisC/COQ6 family ubiquinone biosynthesis hydroxylase -
H3309_RS10425 2071291..2072778 + 1488 WP_182294656.1 AbgT family transporter -
H3309_RS10430 2072781..2073566 - 786 WP_182294657.1 succinate dehydrogenase iron-sulfur subunit -
H3309_RS10435 2073766..2074044 - 279 WP_182294658.1 DUF1902 domain-containing protein -
H3309_RS10440 2074175..2074423 + 249 WP_182294659.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
H3309_RS10445 2074410..2074697 + 288 WP_182294660.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H3309_RS10450 2074739..2075224 - 486 WP_182294661.1 hypothetical protein -
H3309_RS10455 2075234..2077021 - 1788 WP_182294662.1 succinate dehydrogenase flavoprotein subunit -
H3309_RS10460 2077023..2077403 - 381 WP_182294663.1 succinate dehydrogenase, hydrophobic membrane anchor protein -
H3309_RS10465 2077403..2077804 - 402 WP_182294664.1 succinate dehydrogenase, cytochrome b556 subunit -
H3309_RS10470 2078105..2078575 - 471 WP_182294665.1 DUF1330 domain-containing protein -
H3309_RS10475 2078559..2078912 - 354 WP_182294666.1 protein kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(10-77)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11026.92 Da        Isoelectric Point: 10.9353

>T169273 WP_182294660.1 NZ_CP059851:2074410-2074697 [Sandaracinobacter sp. M6]
MTTYRLTFLRDAKKEWDKLDSKIRNQFSKKLAERLSNPRIPSAKLAGMPNCYKIKLHSAGYRLVYRVDDGRIVVQVIAVG
KRERSAIYEAANKRI

Download         Length: 288 bp

>T169273 NZ_CP076344:c3593205-3592870 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATACGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTCTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGA
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 8738.97 Da        Isoelectric Point: 3.8345

>AT169273 WP_182294659.1 NZ_CP059851:2074175-2074423 [Sandaracinobacter sp. M6]
MIEPLLASAAVSISNLKKNPSAVIAAAEGAPVAILNRNTPQAYLVPAAAWEALMDQLEDLELAAIVREREGQEEIEVSID
DL

Download         Length: 249 bp

>AT169273 NZ_CP076344:c3593453-3593205 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGGGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References