Detailed information of TA system TA169271

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VapB
• Location: 679153..679742
• Replicon: chromosome
• Accession: NZ_CP059851
• Organism: Sandaracinobacter sp. M6

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: H3309_RS03370
• Protein ID: WP_182297375.1
• Coordinates: 679153..679521 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: H3309_RS03375
• Protein ID: WP_182297376.1
• Coordinates: 679518..679742 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H3309_RS03340	674242..674610	+	369	WP_182297370.1	hypothetical protein	-
H3309_RS03345	674615..675901	-	1287	WP_182297371.1	N-succinylarginine dihydrolase	-
H3309_RS03350	675901..677301	-	1401	WP_182297372.1	succinylglutamate-semialdehyde dehydrogenase	-
H3309_RS03355	677288..678301	-	1014	WP_182298462.1	arginine N-succinyltransferase	-
H3309_RS03360	678391..678846	+	456	WP_182297373.1	Lrp/AsnC family transcriptional regulator	-
H3309_RS03365	678882..679058	-	177	WP_182297374.1	YdcH family protein	-
H3309_RS03370	679153..679521	-	369	WP_182297375.1	VapC toxin family PIN domain ribonuclease	Toxin
H3309_RS03375	679518..679742	-	225	WP_182297376.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
H3309_RS03380	679800..681173	-	1374	WP_182297377.1	dihydrolipoyl dehydrogenase	-
H3309_RS03385	681173..681586	-	414	WP_182297378.1	hypothetical protein	-
H3309_RS03390	681583..681852	-	270	WP_182297379.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
H3309_RS03395	681911..683317	-	1407	WP_182297380.1	pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase	-
H3309_RS03400	683322..683621	-	300	WP_182297381.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	648356..698740	50384

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Bacterial antitoxin of type II TA system, VapB (1-39)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13671.05 Da
• Isoelectric Point: 6.4836

>T169271 WP_182297375.1 NZ_CP059851:c679521-679153 [Sandaracinobacter sp. M6]
MILADTNIWLVHFRQPDAKLTELVSNRQLHVHPMVLGEIAVGPIIGRDDVLTMLDELPRCETASHEEVMQFIESVPLHSR
KLSYIDVHLLAATMLTAGCRLWTRDRRLLAAAGLLKLGADLP

Nucleotide

• Length: 369 bp

>T169271 NZ_CP076344:c2825629-2825375 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 8223.37 Da
• Isoelectric Point: 5.0338

>AT169271 WP_182297376.1 NZ_CP059851:c679742-679518 [Sandaracinobacter sp. M6]
MRTTVTLDDRLIERAAVYSGLKEKSAVINEALRSYVAWQAGLRLAALGGTMPDLEITPRKRPWDEFGADSEPFA

Nucleotide

• Length: 225 bp

>AT169271 NZ_CP076344:c2825877-2825626 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA