Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2511888..2512627 Replicon chromosome
Accession NZ_CP059849
Organism Citrobacter freundii strain 3863

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag H4O05_RS12205 Protein ID WP_185228815.1
Coordinates 2512142..2512627 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag H4O05_RS12200 Protein ID WP_185228814.1
Coordinates 2511888..2512154 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H4O05_RS12180 (2507887) 2507887..2509230 + 1344 WP_003843660.1 fimbrial protein -
H4O05_RS12185 (2509238) 2509238..2509894 + 657 WP_128295835.1 molecular chaperone -
H4O05_RS12190 (2509950) 2509950..2510714 + 765 WP_016150238.1 winged helix-turn-helix domain-containing protein -
H4O05_RS12195 (2510701) 2510701..2511171 + 471 WP_016150237.1 hypothetical protein -
H4O05_RS12200 (2511888) 2511888..2512154 + 267 WP_185228814.1 DUF1778 domain-containing protein Antitoxin
H4O05_RS12205 (2512142) 2512142..2512627 + 486 WP_185228815.1 GNAT family N-acetyltransferase Toxin
H4O05_RS12210 (2513436) 2513436..2514386 + 951 WP_185228816.1 CBASS oligonucleotide cyclase -
H4O05_RS12215 (2514383) 2514383..2514874 + 492 WP_185228817.1 hypothetical protein -
H4O05_RS12220 (2514871) 2514871..2515773 + 903 WP_221629022.1 ATP-binding protein -
H4O05_RS12225 (2515775) 2515775..2516941 + 1167 WP_185228818.1 hypothetical protein -
H4O05_RS12230 (2516938) 2516938..2517477 + 540 WP_185228819.1 3'-5' exonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-152)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17709.47 Da        Isoelectric Point: 9.8567

>T169265 WP_185228815.1 NZ_CP059849:2512142-2512627 [Citrobacter freundii]
VGCVTAPEPLSSFHQVVEFVSGKAVLDDWLKQRGLKNQALGAARTFVVCKKDTKQAAGFYSLATGSVNHAEATGSFRRNM
PDPIPVIILARLAVDLSFHGKGLDADLLHDAVLRCYRVAQNIGVRAIMVHALTEEAKNFYIHHGFKPSQTQQRTLFLKLP
Q

Download         Length: 486 bp

>T169265 NZ_CP076344:1003194-1003592 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGAAGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGTGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGCAGCGCATTTGGTATATTGTCAGGGCGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10091.52 Da        Isoelectric Point: 4.3721

>AT169265 WP_185228814.1 NZ_CP059849:2511888-2512154 [Citrobacter freundii]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFSDEQYAEFIDMLDAPVADDPIIDKLL
ARKPQWDV

Download         Length: 267 bp

>AT169265 NZ_CP076344:1002898-1003191 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
TGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTTGAAGCATTAATGGACATGCTTG
CAGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCGAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References