Detailed information of TA system TA169252

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 2805923..2806836
• Replicon: chromosome
• Accession: NZ_CP059843
• Organism: Cobetia sp. 4B

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: H2O77_RS11545
• Protein ID: WP_082388599.1
• Coordinates: 2806372..2806836 (+)
• Length: 155 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: H2O77_RS11540
• Protein ID: WP_215823128.1
• Coordinates: 2805923..2806375 (+)
• Length: 151 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H2O77_RS11520 (H2O77_11505)	2801568..2803034	-	1467	WP_215823126.1	aldehyde dehydrogenase family protein	-
H2O77_RS11525 (H2O77_11510)	2803149..2804030	+	882	WP_131432367.1	LysR family transcriptional regulator	-
H2O77_RS11530 (H2O77_11515)	2804183..2804647	+	465	WP_077373944.1	methylenetetrahydrofolate reductase C-terminal domain-containing protein	-
H2O77_RS11535 (H2O77_11520)	2804644..2805648	+	1005	WP_215823127.1	methylenetetrahydrofolate reductase	-
H2O77_RS11540 (H2O77_11525)	2805923..2806375	+	453	WP_215823128.1	DUF2384 domain-containing protein	Antitoxin
H2O77_RS11545 (H2O77_11530)	2806372..2806836	+	465	WP_082388599.1	RES family NAD+ phosphorylase	Toxin
H2O77_RS11550 (H2O77_11535)	2807612..2807992	-	381	WP_276315203.1	helix-turn-helix domain-containing protein	-
H2O77_RS11555 (H2O77_11540)	2808291..2808476	+	186	WP_215823129.1	DUF2188 domain-containing protein	-
H2O77_RS11560 (H2O77_11545)	2809682..2810407	+	726	WP_215823130.1	gluconate 2-dehydrogenase subunit 3 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2805923..2824330	18407

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (7-149)

Antitoxin

• Antitoxin Xre (19-150)

Sequences

Toxin

Protein

• Length: 155 a.a.
• Molecular weight: 17271.73 Da
• Isoelectric Point: 4.5238

>T169252 WP_082388599.1 NZ_CP059843:2806372-2806836 [Cobetia sp. 4B]
MTVVRGYRLVKRKWLKTAFDGEGARLYGGRWNSKGKACVYLASTESLAMLEVMVHLEDNQLLKEYALLEVTFREEVLMQL
PEDVLPADWRAEPAPPSTAEIGDDWLEGQSSLVLAVPSVVAPRETNYLVNPEHPAFLALAQGAEEVDFTPDRRL

Nucleotide

• Length: 465 bp

>T169252 NZ_CP076318:c3054131-3054024 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Protein

• Length: 151 a.a.
• Molecular weight: 16522.09 Da
• Isoelectric Point: 10.0116

>AT169252 WP_215823128.1 NZ_CP059843:2805923-2806375 [Cobetia sp. 4B]
MQAAIKEYRPKPAARKDDFWRALGLPSRGAKLHEALNAGISYKVYTKLTEASGLESKELARYVVIPPATLKRRADTGYFK
PAEGDRLYRFAEVYKSAVDLFEGDKAKAKEWLLSPVRGLGGRLPVEMVATTAGAEAVLDLIGRLEHGVFA

Nucleotide

• Length: 453 bp

>AT169252 NZ_CP076318:3054179-3054245 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT