Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2197909..2198744 Replicon chromosome
Accession NZ_CP059835
Organism Escherichia coli strain tcmA_3

Toxin (Protein)


Gene name yeeV Uniprot ID A0A2S4A272
Locus tag GQF93_RS10710 Protein ID WP_001094443.1
Coordinates 2198367..2198744 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B7LDN9
Locus tag GQF93_RS10705 Protein ID WP_001285607.1
Coordinates 2197909..2198277 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQF93_RS10670 (2193640) 2193640..2194524 + 885 WP_024166630.1 50S ribosome-binding GTPase -
GQF93_RS10675 (2194643) 2194643..2195322 + 680 Protein_2115 hypothetical protein -
GQF93_RS10680 (2195352) 2195352..2195561 + 210 WP_023155727.1 DUF905 family protein -
GQF93_RS10685 (2195652) 2195652..2196470 + 819 WP_001234693.1 DUF932 domain-containing protein -
GQF93_RS10690 (2196562) 2196562..2197047 + 486 WP_032153711.1 antirestriction protein -
GQF93_RS10695 (2197063) 2197063..2197538 + 476 Protein_2119 RadC family protein -
GQF93_RS10700 (2197607) 2197607..2197829 + 223 Protein_2120 DUF987 domain-containing protein -
GQF93_RS10705 (2197909) 2197909..2198277 + 369 WP_001285607.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
GQF93_RS10710 (2198367) 2198367..2198744 + 378 WP_001094443.1 TA system toxin CbtA family protein Toxin
GQF93_RS10715 (2198741) 2198741..2199234 + 494 Protein_2123 DUF5983 family protein -
GQF93_RS10720 (2199246) 2199246..2199443 + 198 WP_000839265.1 DUF957 domain-containing protein -
GQF93_RS10725 (2199528) 2199528..2200393 + 866 Protein_2125 DUF4942 domain-containing protein -
GQF93_RS10730 (2200465) 2200465..2200728 + 264 WP_025492088.1 type II toxin-antitoxin system ParD family antitoxin -
GQF93_RS10735 (2200725) 2200725..2201051 + 327 WP_000779483.1 type II toxin-antitoxin system RelE/ParE family toxin -
GQF93_RS10740 (2201515) 2201515..2202777 + 1263 WP_086590270.1 integrase arm-type DNA-binding domain-containing protein -
GQF93_RS10745 (2202993) 2202993..2203690 + 698 WP_244565313.1 IS1-like element IS1A family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2157067..2204292 47225


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14058.97 Da        Isoelectric Point: 7.3523

>T169196 WP_001094443.1 NZ_CP059835:2198367-2198744 [Escherichia coli]
MNTLPDTHVREASHCQSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMARDNYRTVNNITLGKHPGAKQ

Download         Length: 378 bp

>T169196 NZ_CP076301:c3021516-3021409 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13689.53 Da        Isoelectric Point: 6.4669

>AT169196 WP_001285607.1 NZ_CP059835:2197909-2198277 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKRLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT169196 NZ_CP076301:3021564-3021630 [Escherichia coli]
GGTCTAGATGCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S4A272

Antitoxin

Source ID Structure
AlphaFold DB A0A1M0JLU8

References