Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 2061384..2061979 Replicon chromosome
Accession NZ_CP059835
Organism Escherichia coli strain tcmA_3

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag GQF93_RS10015 Protein ID WP_000239579.1
Coordinates 2061384..2061734 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID U9Y2K1
Locus tag GQF93_RS10020 Protein ID WP_001223208.1
Coordinates 2061728..2061979 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GQF93_RS09995 (2056660) 2056660..2057682 - 1023 WP_001296689.1 ABC transporter permease -
GQF93_RS10000 (2057696) 2057696..2059198 - 1503 WP_000205791.1 sugar ABC transporter ATP-binding protein -
GQF93_RS10005 (2059508) 2059508..2060464 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
GQF93_RS10010 (2060774) 2060774..2061304 + 531 WP_000055072.1 inorganic diphosphatase -
GQF93_RS10015 (2061384) 2061384..2061734 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
GQF93_RS10020 (2061728) 2061728..2061979 - 252 WP_001223208.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
GQF93_RS10025 (2062192) 2062192..2062533 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
GQF93_RS10030 (2062536) 2062536..2066315 - 3780 WP_000060943.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T169195 WP_000239579.1 NZ_CP059835:c2061734-2061384 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T169195 NZ_CP076301:c3021033-3020926 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CATGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9271.58 Da        Isoelectric Point: 4.4201

>AT169195 WP_001223208.1 NZ_CP059835:c2061979-2061728 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT169195 NZ_CP076301:3021081-3021147 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LQ26

References