Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 7661..8180 Replicon plasmid pBP3378_P6
Accession NZ_CP059799
Organism Enterococcus faecium strain BP3378

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag HI838_RS15620 Protein ID WP_000588503.1
Coordinates 7923..8180 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag HI838_RS15615 Protein ID WP_000388479.1
Coordinates 7661..7930 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HI838_RS15580 3257..3673 - 417 WP_182486064.1 hypothetical protein -
HI838_RS15585 3675..3956 - 282 WP_002347613.1 hypothetical protein -
HI838_RS15590 4302..4547 + 246 WP_002311817.1 hypothetical protein -
HI838_RS15595 4849..4944 - 96 WP_106913803.1 type I toxin-antitoxin system Fst family toxin -
HI838_RS15600 5648..6328 - 681 WP_001015311.1 IS6-like element IS1216 family transposase -
HI838_RS15605 6404..6970 + 567 Protein_8 hypothetical protein -
HI838_RS15610 7351..7530 + 180 WP_001120991.1 hypothetical protein -
HI838_RS15615 7661..7930 + 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HI838_RS15620 7923..8180 + 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
HI838_RS15625 8639..8794 + 156 WP_002347142.1 hypothetical protein -
HI838_RS15630 8818..9405 + 588 Protein_13 hypothetical protein -
HI838_RS15635 9560..10879 + 1320 WP_000202380.1 IS1380-like element IS1678 family transposase -
HI838_RS15640 11083..11325 + 243 Protein_15 hypothetical protein -
HI838_RS15645 11490..12104 - 615 WP_001261742.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..16641 16641
- inside IScluster/Tn - - 1657..10879 9222


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T169167 WP_000588503.1 NZ_CP059799:7923-8180 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

>T169167 NZ_CP076285:c3639916-3639641 [Escherichia coli]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT169167 WP_000388479.1 NZ_CP059799:7661-7930 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp

>AT169167 NZ_CP076285:c3639644-3639285 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCAGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References