Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Txe-Axe/Txe-RelB |
Location | 18210..18729 | Replicon | plasmid pBP3378_P1 |
Accession | NZ_CP059794 | ||
Organism | Enterococcus faecium strain BP3378 |
Toxin (Protein)
Gene name | Txe | Uniprot ID | Q848U6 |
Locus tag | HI838_RS13585 | Protein ID | WP_000588503.1 |
Coordinates | 18472..18729 (+) | Length | 86 a.a. |
Antitoxin (Protein)
Gene name | Axe | Uniprot ID | Q83WJ8 |
Locus tag | HI838_RS13580 | Protein ID | WP_000388479.1 |
Coordinates | 18210..18479 (+) | Length | 90 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HI838_RS13535 | 13407..14306 | + | 900 | WP_002303312.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
HI838_RS13540 | 14309..14794 | + | 486 | WP_002303313.1 | single-stranded DNA-binding protein | - |
HI838_RS13545 | 14935..15138 | - | 204 | WP_002316074.1 | putative holin-like toxin | - |
HI838_RS13550 | 15213..15473 | + | 261 | WP_002295623.1 | hypothetical protein | - |
HI838_RS13555 | 15910..16116 | + | 207 | WP_002347218.1 | hypothetical protein | - |
HI838_RS13560 | 16116..16367 | + | 252 | WP_002296238.1 | hypothetical protein | - |
HI838_RS13565 | 16382..16819 | + | 438 | WP_002300851.1 | hypothetical protein | - |
HI838_RS13570 | 16812..17519 | + | 708 | WP_002303117.1 | hypothetical protein | - |
HI838_RS13575 | 17900..18079 | + | 180 | WP_001120991.1 | hypothetical protein | - |
HI838_RS13580 | 18210..18479 | + | 270 | WP_000388479.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
HI838_RS13585 | 18472..18729 | + | 258 | WP_000588503.1 | Txe/YoeB family addiction module toxin | Toxin |
HI838_RS13590 | 19188..19343 | + | 156 | WP_002347142.1 | hypothetical protein | - |
HI838_RS13595 | 19367..20191 | + | 825 | WP_001809248.1 | hypothetical protein | - |
HI838_RS13600 | 20356..20970 | - | 615 | WP_001261742.1 | recombinase family protein | - |
HI838_RS13605 | 21208..21630 | + | 423 | WP_002303116.1 | hypothetical protein | - |
HI838_RS13610 | 21640..21843 | + | 204 | WP_002299573.1 | hypothetical protein | - |
HI838_RS13615 | 22054..22638 | + | 585 | WP_002299575.1 | recombinase family protein | - |
HI838_RS13620 | 22827..23507 | - | 681 | WP_010861579.1 | IS6-like element IS1216 family transposase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | aac(6')-aph(2'') | - | 1..227172 | 227172 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 10206.53 Da Isoelectric Point: 8.4369
>T169163 WP_000588503.1 NZ_CP059794:18472-18729 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY
Download Length: 258 bp
>T169163 NZ_CP076285:c2611145-2610747 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTGATTGAAGGTTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGATTGGAGCTAA
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTGATTGAAGGTTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGATTGGAGCTAA
Antitoxin
Download Length: 90 a.a. Molecular weight: 10373.51 Da Isoelectric Point: 4.4346
>AT169163 WP_000388479.1 NZ_CP059794:18210-18479 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD
Download Length: 270 bp
>AT169163 NZ_CP076285:c2611372-2611145 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAGGATGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTCTGA
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAGGATGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A828ZXQ8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A828ZWU7 |