Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 7686..8205 Replicon plasmid pBA17124_P3
Accession NZ_CP059787
Organism Enterococcus faecium strain BA17124

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag HI828_RS14215 Protein ID WP_000588503.1
Coordinates 7948..8205 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag HI828_RS14210 Protein ID WP_000388479.1
Coordinates 7686..7955 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HI828_RS14175 3257..3673 - 417 WP_001232859.1 hypothetical protein -
HI828_RS14180 3676..3960 - 285 WP_000353844.1 hypothetical protein -
HI828_RS14185 4305..4550 + 246 WP_002311817.1 hypothetical protein -
HI828_RS14190 4852..4947 - 96 WP_106913803.1 type I toxin-antitoxin system Fst family toxin -
HI828_RS14195 5673..6353 - 681 WP_001015311.1 IS6-like element IS1216 family transposase -
HI828_RS14200 6429..6995 + 567 Protein_8 hypothetical protein -
HI828_RS14205 7376..7555 + 180 WP_001120991.1 hypothetical protein -
HI828_RS14210 7686..7955 + 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HI828_RS14215 7948..8205 + 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
HI828_RS14220 8843..9430 + 588 Protein_12 hypothetical protein -
HI828_RS14225 9585..10904 + 1320 WP_000202380.1 IS1380-like element IS1678 family transposase -
HI828_RS14230 11108..11350 + 243 Protein_14 hypothetical protein -
HI828_RS14235 11515..12129 - 615 WP_001261742.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..16666 16666
- inside IScluster/Tn - - 1657..10904 9247


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T169160 WP_000588503.1 NZ_CP059787:7948-8205 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

>T169160 NZ_CP076285:c1911811-1911708 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT169160 WP_000388479.1 NZ_CP059787:7686-7955 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp

>AT169160 NZ_CP076285:1911670-1911941 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References