Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Txe-Axe/Txe-RelB |
Location | 22612..23131 | Replicon | plasmid pA11051_P3 |
Accession | NZ_CP059767 | ||
Organism | Enterococcus faecium strain A11051 |
Toxin (Protein)
Gene name | Txe | Uniprot ID | Q848U6 |
Locus tag | HI861_RS15190 | Protein ID | WP_000588503.1 |
Coordinates | 22612..22869 (-) | Length | 86 a.a. |
Antitoxin (Protein)
Gene name | Axe | Uniprot ID | Q83WJ8 |
Locus tag | HI861_RS15195 | Protein ID | WP_000388479.1 |
Coordinates | 22862..23131 (-) | Length | 90 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HI861_RS15165 | 18688..19302 | + | 615 | WP_001261742.1 | recombinase family protein | - |
HI861_RS15170 | 19467..19709 | - | 243 | Protein_23 | hypothetical protein | - |
HI861_RS15175 | 19913..21232 | - | 1320 | WP_000202380.1 | IS1380-like element IS1678 family transposase | - |
HI861_RS15180 | 21387..21974 | - | 588 | Protein_25 | hypothetical protein | - |
HI861_RS15185 | 21998..22153 | - | 156 | WP_002347142.1 | hypothetical protein | - |
HI861_RS15190 | 22612..22869 | - | 258 | WP_000588503.1 | Txe/YoeB family addiction module toxin | Toxin |
HI861_RS15195 | 22862..23131 | - | 270 | WP_000388479.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
HI861_RS15200 | 23262..23441 | - | 180 | WP_001120991.1 | hypothetical protein | - |
HI861_RS15205 | 23822..24388 | - | 567 | Protein_30 | hypothetical protein | - |
HI861_RS15210 | 24464..25144 | + | 681 | WP_001015311.1 | IS6-like element IS1216 family transposase | - |
HI861_RS15215 | 25870..25965 | + | 96 | WP_106913803.1 | type I toxin-antitoxin system Fst family toxin | - |
HI861_RS15220 | 26267..26512 | - | 246 | WP_002311817.1 | hypothetical protein | - |
HI861_RS15225 | 26857..27138 | + | 282 | WP_086325443.1 | hypothetical protein | - |
HI861_RS15230 | 27140..27556 | + | 417 | WP_001232859.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | VanHAX | - | 1..28402 | 28402 | |
- | inside | IScluster/Tn | - | - | 19913..25144 | 5231 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 10206.53 Da Isoelectric Point: 8.4369
>T169152 WP_000588503.1 NZ_CP059767:c22869-22612 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY
Download Length: 258 bp
>T169152 NZ_CP076283:c67750-67601 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGGTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTTACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
ATGACGAAATATGCCCTTATCGGGGTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTTACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA
Antitoxin
Download Length: 90 a.a. Molecular weight: 10373.51 Da Isoelectric Point: 4.4346
>AT169152 WP_000388479.1 NZ_CP059767:c23131-22862 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD
Download Length: 270 bp
>AT169152 NZ_CP076283:67794-67855 [Escherichia coli]
TTAAGGTACTTCATGCAGGCCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT
TTAAGGTACTTCATGCAGGCCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A828ZXQ8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A828ZWU7 |