Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 22612..23131 Replicon plasmid pA11051_P3
Accession NZ_CP059767
Organism Enterococcus faecium strain A11051

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag HI861_RS15190 Protein ID WP_000588503.1
Coordinates 22612..22869 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag HI861_RS15195 Protein ID WP_000388479.1
Coordinates 22862..23131 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HI861_RS15165 18688..19302 + 615 WP_001261742.1 recombinase family protein -
HI861_RS15170 19467..19709 - 243 Protein_23 hypothetical protein -
HI861_RS15175 19913..21232 - 1320 WP_000202380.1 IS1380-like element IS1678 family transposase -
HI861_RS15180 21387..21974 - 588 Protein_25 hypothetical protein -
HI861_RS15185 21998..22153 - 156 WP_002347142.1 hypothetical protein -
HI861_RS15190 22612..22869 - 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
HI861_RS15195 22862..23131 - 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HI861_RS15200 23262..23441 - 180 WP_001120991.1 hypothetical protein -
HI861_RS15205 23822..24388 - 567 Protein_30 hypothetical protein -
HI861_RS15210 24464..25144 + 681 WP_001015311.1 IS6-like element IS1216 family transposase -
HI861_RS15215 25870..25965 + 96 WP_106913803.1 type I toxin-antitoxin system Fst family toxin -
HI861_RS15220 26267..26512 - 246 WP_002311817.1 hypothetical protein -
HI861_RS15225 26857..27138 + 282 WP_086325443.1 hypothetical protein -
HI861_RS15230 27140..27556 + 417 WP_001232859.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid VanHAX - 1..28402 28402
- inside IScluster/Tn - - 19913..25144 5231


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T169152 WP_000588503.1 NZ_CP059767:c22869-22612 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

>T169152 NZ_CP076283:c67750-67601 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGGTGCTCGCCGTGTGCGCCACGGTGTTGTGTTTTTTACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT169152 WP_000388479.1 NZ_CP059767:c23131-22862 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp

>AT169152 NZ_CP076283:67794-67855 [Escherichia coli]
TTAAGGTACTTCATGCAGGCCTCACGAGTTAATGGATTAACAAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References