Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 50809..51328 Replicon plasmid pA11051_P1
Accession NZ_CP059765
Organism Enterococcus faecium strain A11051

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag HI861_RS13450 Protein ID WP_000588503.1
Coordinates 51071..51328 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag HI861_RS13445 Protein ID WP_000388479.1
Coordinates 50809..51078 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HI861_RS13400 46006..46905 + 900 WP_002303312.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
HI861_RS13405 46908..47393 + 486 WP_002303313.1 single-stranded DNA-binding protein -
HI861_RS13410 47534..47737 - 204 WP_002316074.1 putative holin-like toxin -
HI861_RS13415 47812..48072 + 261 WP_002295623.1 hypothetical protein -
HI861_RS13420 48509..48715 + 207 WP_002347218.1 hypothetical protein -
HI861_RS13425 48715..48966 + 252 WP_002296238.1 hypothetical protein -
HI861_RS13430 48981..49418 + 438 WP_002300851.1 hypothetical protein -
HI861_RS13435 49411..50118 + 708 WP_002303117.1 hypothetical protein -
HI861_RS13440 50499..50678 + 180 WP_001120991.1 hypothetical protein -
HI861_RS13445 50809..51078 + 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HI861_RS13450 51071..51328 + 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
HI861_RS13455 51787..51942 + 156 WP_002347142.1 hypothetical protein -
HI861_RS13460 51966..52790 + 825 WP_001809248.1 hypothetical protein -
HI861_RS13465 52955..53569 - 615 WP_001261742.1 recombinase family protein -
HI861_RS13470 53807..54229 + 423 WP_002303116.1 hypothetical protein -
HI861_RS13475 54239..54442 + 204 WP_002299573.1 hypothetical protein -
HI861_RS13480 54653..55237 + 585 WP_002299575.1 recombinase family protein -
HI861_RS13485 55426..56106 - 681 WP_010861579.1 IS6-like element IS1216 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid tet(L) / ant(6)-Ia / aph(3')-III / erm(B) / aac(6')-aph(2'') - 1..294680 294680


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T169149 WP_000588503.1 NZ_CP059765:51071-51328 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

>T169149 NZ_CP076282:4677397-4677747 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTAGGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT169149 WP_000388479.1 NZ_CP059765:50809-51078 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp

>AT169149 NZ_CP076282:4677152-4677403 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References