Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | Txe-Axe/Txe-RelB |
Location | 50809..51328 | Replicon | plasmid pA11051_P1 |
Accession | NZ_CP059765 | ||
Organism | Enterococcus faecium strain A11051 |
Toxin (Protein)
Gene name | Txe | Uniprot ID | Q848U6 |
Locus tag | HI861_RS13450 | Protein ID | WP_000588503.1 |
Coordinates | 51071..51328 (+) | Length | 86 a.a. |
Antitoxin (Protein)
Gene name | Axe | Uniprot ID | Q83WJ8 |
Locus tag | HI861_RS13445 | Protein ID | WP_000388479.1 |
Coordinates | 50809..51078 (+) | Length | 90 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
HI861_RS13400 | 46006..46905 | + | 900 | WP_002303312.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | - |
HI861_RS13405 | 46908..47393 | + | 486 | WP_002303313.1 | single-stranded DNA-binding protein | - |
HI861_RS13410 | 47534..47737 | - | 204 | WP_002316074.1 | putative holin-like toxin | - |
HI861_RS13415 | 47812..48072 | + | 261 | WP_002295623.1 | hypothetical protein | - |
HI861_RS13420 | 48509..48715 | + | 207 | WP_002347218.1 | hypothetical protein | - |
HI861_RS13425 | 48715..48966 | + | 252 | WP_002296238.1 | hypothetical protein | - |
HI861_RS13430 | 48981..49418 | + | 438 | WP_002300851.1 | hypothetical protein | - |
HI861_RS13435 | 49411..50118 | + | 708 | WP_002303117.1 | hypothetical protein | - |
HI861_RS13440 | 50499..50678 | + | 180 | WP_001120991.1 | hypothetical protein | - |
HI861_RS13445 | 50809..51078 | + | 270 | WP_000388479.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
HI861_RS13450 | 51071..51328 | + | 258 | WP_000588503.1 | Txe/YoeB family addiction module toxin | Toxin |
HI861_RS13455 | 51787..51942 | + | 156 | WP_002347142.1 | hypothetical protein | - |
HI861_RS13460 | 51966..52790 | + | 825 | WP_001809248.1 | hypothetical protein | - |
HI861_RS13465 | 52955..53569 | - | 615 | WP_001261742.1 | recombinase family protein | - |
HI861_RS13470 | 53807..54229 | + | 423 | WP_002303116.1 | hypothetical protein | - |
HI861_RS13475 | 54239..54442 | + | 204 | WP_002299573.1 | hypothetical protein | - |
HI861_RS13480 | 54653..55237 | + | 585 | WP_002299575.1 | recombinase family protein | - |
HI861_RS13485 | 55426..56106 | - | 681 | WP_010861579.1 | IS6-like element IS1216 family transposase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Mobilizable plasmid | tet(L) / ant(6)-Ia / aph(3')-III / erm(B) / aac(6')-aph(2'') | - | 1..294680 | 294680 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 10206.53 Da Isoelectric Point: 8.4369
>T169149 WP_000588503.1 NZ_CP059765:51071-51328 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY
Download Length: 258 bp
>T169149 NZ_CP076282:4677397-4677747 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTAGGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTAGGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA
Antitoxin
Download Length: 90 a.a. Molecular weight: 10373.51 Da Isoelectric Point: 4.4346
>AT169149 WP_000388479.1 NZ_CP059765:50809-51078 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD
Download Length: 270 bp
>AT169149 NZ_CP076282:4677152-4677403 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A828ZXQ8 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A828ZWU7 |