Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Txe-Axe/Txe-RelB
Location 18210..18729 Replicon plasmid pA4694_P1
Accession NZ_CP059740
Organism Enterococcus faecium strain A4694

Toxin (Protein)


Gene name Txe Uniprot ID Q848U6
Locus tag HI848_RS13020 Protein ID WP_000588503.1
Coordinates 18472..18729 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name Axe Uniprot ID Q83WJ8
Locus tag HI848_RS13015 Protein ID WP_000388479.1
Coordinates 18210..18479 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HI848_RS12970 13407..14306 + 900 WP_002303312.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
HI848_RS12975 14309..14794 + 486 WP_002303313.1 single-stranded DNA-binding protein -
HI848_RS12980 14935..15138 - 204 WP_002316074.1 putative holin-like toxin -
HI848_RS12985 15213..15473 + 261 WP_002295623.1 hypothetical protein -
HI848_RS12990 15910..16116 + 207 WP_002347218.1 hypothetical protein -
HI848_RS12995 16116..16367 + 252 WP_002296238.1 hypothetical protein -
HI848_RS13000 16382..16819 + 438 WP_002300851.1 hypothetical protein -
HI848_RS13005 16812..17519 + 708 WP_002303117.1 hypothetical protein -
HI848_RS13010 17900..18079 + 180 WP_001120991.1 hypothetical protein -
HI848_RS13015 18210..18479 + 270 WP_000388479.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HI848_RS13020 18472..18729 + 258 WP_000588503.1 Txe/YoeB family addiction module toxin Toxin
HI848_RS13030 20736..21560 + 825 WP_001809248.1 hypothetical protein -
HI848_RS13035 21725..22339 - 615 WP_001261742.1 recombinase family protein -
HI848_RS13040 22577..22999 + 423 WP_002303116.1 hypothetical protein -
HI848_RS13045 23009..23212 + 204 WP_002299573.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid aac(6')-aph(2'') - 1..229795 229795


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10206.53 Da        Isoelectric Point: 8.4369

>T169128 WP_000588503.1 NZ_CP059740:18472-18729 [Enterococcus faecium]
MIKAWSDDAWDDYLYWHEQGNKSNIKKINKLIKDIDRSPFAGLGKPEPLKHDLSGKWSRRITDEHRLIYRVENETIFIYS
AKDHY

Download         Length: 258 bp

>T169128 NZ_CP076280:138785-139072 [Escherichia coli]
ATGAGGTATCAGATAAAATTCAGGGAAGATGCGCTGAAAGAGTGGCAAAAACTGGACAAGGCTATTCAGCAACAGTTTGC
GAAAAAGCTAAAAAAGTGCTGTGACAATCCGCATATTCCTTCCGCAAAACTGCGCGGGATAAAGGACTGCTACAAAATAA
AATTACGTGCGTCAGGTTTTCGCCTGGTCTATCAGGTGATTGACGAACAATTAATTATCGCTGTTGTAGCAGTGGGTAAA
CGTGAGCGCAGTGACGTTTATAATCTTGCCAGTGAAAGAATGAGATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10373.51 Da        Isoelectric Point: 4.4346

>AT169128 WP_000388479.1 NZ_CP059740:18210-18479 [Enterococcus faecium]
MEAVAYSNFRQNLRSYMKQVNEDAETLIVTSKDVEDTVVVLSKRDYDSMQETLRTLSNNYVMEKIRRGDEQFSKGAFKTH
DLIEVESDD

Download         Length: 270 bp

>AT169128 NZ_CP076280:138537-138788 [Escherichia coli]
ATGCCTAACATTATTCTCAGTGATACAAGCGCCAGTGTCAGCGAGCTGAAGAAAAACCCGATGGCGACAGTCAGCGCCGG
TGATGGTTTCCCGGTCGCTATCCTGAACCGTAATCAGCCTGCTTTCTACTGTGTACCCGCAGAGCTGTACGAAAAGATGC
TTGATGCCTTGGACGATCAGGAGTTGGTTAAACTGGTAGCCGAACGCAGCAACCAACCGCTGCATGATGTAGATCTGGAT
AAATACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A828ZXQ8

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZWU7

References