169125

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 6222872..6223397 Replicon chromosome
Accession NZ_CP059738
Organism Pseudomonas sp. 29A

Toxin (Protein)


Gene name relE Uniprot ID A0A7H8GF58
Locus tag H3303_RS27495 Protein ID WP_016984129.1
Coordinates 6223101..6223397 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A4R7UU95
Locus tag H3303_RS27490 Protein ID WP_016984130.1
Coordinates 6222872..6223111 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H3303_RS27465 6218662..6219123 + 462 WP_007910890.1 GNAT family N-acetyltransferase -
H3303_RS27470 6219353..6220003 + 651 WP_034153744.1 DedA family protein -
H3303_RS27475 6220008..6220820 + 813 WP_175553120.1 zinc-dependent peptidase -
H3303_RS27480 6220933..6221460 + 528 WP_003205933.1 inorganic diphosphatase -
H3303_RS27485 6221684..6222430 + 747 WP_016984131.1 helix-turn-helix transcriptional regulator -
H3303_RS27490 6222872..6223111 + 240 WP_016984130.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
H3303_RS27495 6223101..6223397 + 297 WP_016984129.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H3303_RS27500 6223452..6224264 - 813 WP_175553119.1 DUF2135 domain-containing protein -
H3303_RS27505 6224268..6225887 - 1620 WP_175553118.1 DUF2300 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-62)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11651.55 Da        Isoelectric Point: 9.6908

>T169125 WP_016984129.1 NZ_CP059738:6223101-6223397 [Pseudomonas sp. 29A]
MTYNLEFDRRALKEWNKLGDTVRHQFKKKLTEVLENPRIEANRLRELPDCYKVKLKSAGYRLIYQVLDQEIVVFVIAIGK
REREAAYEVAQDRLSLLP

Download         Length: 297 bp

>T169125 NZ_CP076279:4481609-4481920 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTTTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8865.24 Da        Isoelectric Point: 4.6017

>AT169125 WP_016984130.1 NZ_CP059738:6222872-6223111 [Pseudomonas sp. 29A]
MASINIRIDDDLKQRSFAELEKLGVTPSELLRQTLQYVAERGKLPFKAALLSEEDEVLIAVVTERLAAPQRVKVSLDDL

Download         Length: 240 bp

>AT169125 NZ_CP076279:4481921-4482211 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H8GF58

Antitoxin

Source ID Structure
AlphaFold DB A0A4R7UU95

References