Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PP_4151-4152/excise(antitoxin)
Location 2164904..2165956 Replicon chromosome
Accession NZ_CP059738
Organism Pseudomonas sp. 29A

Toxin (Protein)


Gene name PP_4152 Uniprot ID -
Locus tag H3303_RS09725 Protein ID WP_026000781.1
Coordinates 2164904..2165407 (-) Length 168 a.a.

Antitoxin (Protein)


Gene name PP_4151 Uniprot ID -
Locus tag H3303_RS09730 Protein ID WP_175554979.1
Coordinates 2165489..2165956 (-) Length 156 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H3303_RS09700 2160230..2162218 + 1989 WP_175554982.1 heme lyase CcmF/NrfE family subunit -
H3303_RS09705 2162215..2162751 + 537 WP_007919961.1 DsbE family thiol:disulfide interchange protein -
H3303_RS09710 2162748..2163218 + 471 WP_175554981.1 cytochrome c-type biogenesis protein CcmH -
H3303_RS09715 2163215..2164417 + 1203 WP_175554980.1 c-type cytochrome biogenesis protein CcmI -
H3303_RS09720 2164443..2164847 + 405 WP_016987493.1 hypothetical protein -
H3303_RS09725 2164904..2165407 - 504 WP_026000781.1 PIN domain-containing protein Toxin
H3303_RS09730 2165489..2165956 - 468 WP_175554979.1 helix-turn-helix domain-containing protein Antitoxin
H3303_RS09735 2166464..2166676 + 213 WP_016987496.1 type II toxin-antitoxin system HicA family toxin -
H3303_RS09740 2166676..2167080 + 405 WP_016987497.1 type II toxin-antitoxin system HicB family antitoxin -
H3303_RS09745 2167147..2168334 - 1188 WP_016987498.1 MFS transporter -
H3303_RS09750 2168578..2169198 + 621 WP_175554978.1 hypothetical protein -
H3303_RS09755 2169441..2170439 - 999 WP_016987500.1 sulfate ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-91)

Antitoxin

SinI-like, DNA-binding domain

(84-130)


Sequences

Toxin        


Download         Length: 168 a.a.        Molecular weight: 19012.72 Da        Isoelectric Point: 6.1005

>T169121 WP_026000781.1 NZ_CP059738:c2165407-2164904 [Pseudomonas sp. 29A]
MWLALSGRFRARWSKEIHSEWKRNLLKNRTDLTMEQLDRTSELMDRAIPEACVCDYEELVNGLSLPDQDDRHVLAAAIRC
GAGVIVTFNLKDFPDTQLAPFGFEAQHPDEFVENLFHLNSAAVVAAAQKQRKQLKTPAMDVESFLRLLQRQGLTQSVQAL
EGYRAIL

Download         Length: 504 bp

>T169121 NZ_CP076279:c3322315-3321908 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 156 a.a.        Molecular weight: 17275.76 Da        Isoelectric Point: 6.3819

>AT169121 WP_175554979.1 NZ_CP059738:c2165956-2165489 [Pseudomonas sp. 29A]
MSIVIHPPVTLPVEREIKAAIEGQRALAAYLATQFETQHIQIFDEQNEAHRVELPTSALRLLADILAALAEGNAVKVVPV
HAELTTQEAADLLNVSRPHMIKLLESGEISYHKTGKHRRVRFADLMDYKTRRDSASEQAMALLAEQAQALRTGYE

Download         Length: 468 bp

>AT169121 NZ_CP076279:c3322562-3322296 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References