Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 2420033..2420574 Replicon chromosome
Accession NZ_CP059735
Organism Thalassomonas actiniarum strain A5K-106

Toxin (Protein)


Gene name parE Uniprot ID A0A0D8CMU2
Locus tag SG35_RS10510 Protein ID WP_044836237.1
Coordinates 2420033..2420335 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0D8CLR9
Locus tag SG35_RS10515 Protein ID WP_044836236.1
Coordinates 2420332..2420574 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SG35_RS10485 (SG35_010470) 2415054..2416187 + 1134 WP_044836241.1 hypothetical protein -
SG35_RS10490 (SG35_010475) 2416417..2417616 - 1200 WP_152646848.1 hypothetical protein -
SG35_RS10495 2418080..2418376 + 297 WP_274055418.1 hypothetical protein -
SG35_RS10500 (SG35_010480) 2418578..2419480 + 903 WP_044836239.1 allantoinase PuuE -
SG35_RS10505 (SG35_010485) 2419636..2420004 + 369 WP_044836238.1 DUF1428 domain-containing protein -
SG35_RS10510 (SG35_010490) 2420033..2420335 - 303 WP_044836237.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SG35_RS10515 (SG35_010495) 2420332..2420574 - 243 WP_044836236.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
SG35_RS10520 (SG35_010500) 2420879..2421376 - 498 WP_044836235.1 hypothetical protein -
SG35_RS10525 (SG35_010505) 2421553..2422053 + 501 WP_044836234.1 hypothetical protein -
SG35_RS10530 (SG35_010510) 2422050..2422265 + 216 WP_152646847.1 hypothetical protein -
SG35_RS10535 (SG35_010515) 2422373..2422543 + 171 WP_160298407.1 hypothetical protein -
SG35_RS10540 (SG35_010520) 2422702..2424093 + 1392 WP_044836231.1 IPT/TIG domain-containing protein -
SG35_RS10545 (SG35_010525) 2424379..2424570 + 192 WP_044836230.1 DUF2892 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(4-71)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11365.11 Da        Isoelectric Point: 10.5184

>T169118 WP_044836237.1 NZ_CP059735:c2420335-2420033 [Thalassomonas actiniarum]
MTPFVLTNAANSDLKKIARSTQGKWGNEQRNFYIKQFDDASHMLAKTPLAGKSCDETRAGYKKFPVGSHLIFYIKGENSR
IKIVRILHKRTDVELNLQAP

Download         Length: 303 bp

>T169118 NZ_CP076279:c2821072-2820674 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8834.80 Da        Isoelectric Point: 4.4488

>AT169118 WP_044836236.1 NZ_CP059735:c2420574-2420332 [Thalassomonas actiniarum]
MAKNTSITLGDHFDSFIASQIGSGRYGSASEVIRAGLRLLENTETKTETLRRMLVEGEKSGTADYTFDTFINELDGEIEK

Download         Length: 243 bp

>AT169118 NZ_CP076279:c2821299-2821072 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D8CMU2

Antitoxin

Source ID Structure
AlphaFold DB A0A0D8CLR9

References