Detailed information of TA system TA169117

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 2391606..2392159
• Replicon: chromosome
• Accession: NZ_CP059735
• Organism: Thalassomonas actiniarum strain A5K-106

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: SG35_RS10350
• Protein ID: WP_084693031.1
• Coordinates: 2391606..2391911 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A0D8CLS2
• Locus tag: SG35_RS10355
• Protein ID: WP_044836260.1
• Coordinates: 2391911..2392159 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SG35_RS10325 (SG35_010310)	2386625..2387701	+	1077	WP_044836264.1	succinylglutamate desuccinylase	-
SG35_RS10330 (SG35_010315)	2387903..2388916	+	1014	WP_044836263.1	AraC family transcriptional regulator	-
SG35_RS10335 (SG35_010320)	2389195..2390565	+	1371	WP_053043486.1	cytochrome c peroxidase	-
SG35_RS10340 (SG35_010325)	2390695..2390859	-	165	WP_160298409.1	hypothetical protein	-
SG35_RS10345 (SG35_010330)	2390975..2391463	-	489	WP_044836262.1	energy transducer TonB	-
SG35_RS10350 (SG35_010335)	2391606..2391911	-	306	WP_084693031.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SG35_RS10355 (SG35_010340)	2391911..2392159	-	249	WP_044836260.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
SG35_RS10360 (SG35_010345)	2392636..2393817	+	1182	WP_044836278.1	thiamine pyrophosphate-dependent dehydrogenase E1 component subunit alpha	-
SG35_RS10365 (SG35_010350)	2393820..2394797	+	978	WP_044836259.1	alpha-ketoacid dehydrogenase subunit beta	-
SG35_RS10370 (SG35_010355)	2394808..2396394	+	1587	WP_044836258.1	dihydrolipoyllysine-residue acetyltransferase	-
SG35_RS10375 (SG35_010360)	2396469..2396855	-	387	WP_053043485.1	DoxX family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Antitoxin ParD (3-65)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11915.59 Da
• Isoelectric Point: 10.0508

>T169117 WP_084693031.1 NZ_CP059735:c2391911-2391606 [Thalassomonas actiniarum]
MAKYRVTPQARDALKNIARYTEQQWGKNQRNIYLKNLEAAFNTLAENPKLGKHRADIHEGYYSFAQGQHVIFYLIHRQGI
DIIGIPHKKMDIIHYFHSSNY

Nucleotide

• Length: 306 bp

>T169117 NZ_CP076279:c2335141-2334890 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 8904.83 Da
• Isoelectric Point: 4.3176

>AT169117 WP_044836260.1 NZ_CP059735:c2392159-2391911 [Thalassomonas actiniarum]
MATTSLSLGEHWEAFIKDEIASGRYGSASEVVRDALRTMEERKTKLAALRAHLATGAQQAASGDFVDDFSMDSLIADLDN
NE

Nucleotide

• Length: 249 bp

>AT169117 NZ_CP076279:c2334893-2334639 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGATCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Structures

Antitoxin

• AlphaFold DB: A0A0D8CLS2