Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 1148328..1148878 Replicon chromosome
Accession NZ_CP059734
Organism Thalassomonas viridans strain XOM25

Toxin (Protein)


Gene name parE Uniprot ID A0A0D8CUW9
Locus tag SG34_RS33895 Protein ID WP_044842284.1
Coordinates 1148328..1148618 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0D8CXF7
Locus tag SG34_RS33900 Protein ID WP_044842283.1
Coordinates 1148606..1148878 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SG34_RS33870 (SG34_033775) 1144163..1144702 + 540 WP_053047493.1 OsmC family protein -
SG34_RS33875 (SG34_033780) 1144724..1145464 + 741 WP_053047491.1 cupin domain-containing protein -
SG34_RS33880 (SG34_033785) 1145475..1146617 + 1143 WP_053047489.1 FAD-dependent oxidoreductase -
SG34_RS33885 (SG34_033790) 1146708..1147448 + 741 WP_053047487.1 cupin domain-containing protein -
SG34_RS33890 (SG34_033795) 1147629..1147946 + 318 WP_044842285.1 metalloregulator ArsR/SmtB family transcription factor -
SG34_RS33895 (SG34_033800) 1148328..1148618 - 291 WP_044842284.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SG34_RS33900 (SG34_033805) 1148606..1148878 - 273 WP_044842283.1 CopG family ribbon-helix-helix protein Antitoxin
SG34_RS33905 (SG34_033810) 1149313..1150311 + 999 WP_044842282.1 beta-ketoacyl synthase N-terminal-like domain-containing protein -
SG34_RS33910 (SG34_033815) 1150429..1150752 - 324 WP_274038653.1 hypothetical protein -
SG34_RS33915 (SG34_033820) 1150745..1150936 - 192 WP_274038654.1 hypothetical protein -
SG34_RS33920 (SG34_033825) 1151479..1153644 - 2166 WP_044840292.1 prolyl oligopeptidase family serine peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10654.38 Da        Isoelectric Point: 10.1805

>T169116 WP_044842284.1 NZ_CP059734:c1148618-1148328 [Thalassomonas viridans]
VSQLIWSPPALADVQRIYRFLAPKDPAAARRAVKAIRAGVKILAHQPEVGRPVENMEPAFREWLIDFGSTGYLALYRLAG
DTAVILAVRHQKEAGY

Download         Length: 291 bp

>T169116 NZ_CP076279:c2334893-2334639 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGATCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10499.63 Da        Isoelectric Point: 4.7755

>AT169116 WP_044842283.1 NZ_CP059734:c1148878-1148606 [Thalassomonas viridans]
MATSIKLDDDLKSRIQHLAELRHRSAHWIMREAIRDYVEREEKREAFKQDALNAWEAYQNNGLHLTLEEADAWLAKLEGG
EDDGVPECHN

Download         Length: 273 bp

>AT169116 NZ_CP076279:c2335141-2334890 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D8CUW9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D8CXF7

References