Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 5448366..5448894 Replicon chromosome
Accession NZ_CP059733
Organism Thalassomonas viridans strain XOM25

Toxin (Protein)


Gene name relE Uniprot ID A0A0D8D030
Locus tag SG34_RS24155 Protein ID WP_044841960.1
Coordinates 5448366..5448653 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0D8CZ35
Locus tag SG34_RS24160 Protein ID WP_044841961.1
Coordinates 5448643..5448894 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SG34_RS24135 (SG34_024025) 5444298..5445626 - 1329 WP_274038412.1 DcaP family trimeric outer membrane transporter -
SG34_RS24140 (SG34_024030) 5445863..5446999 - 1137 WP_044842231.1 ISAs1 family transposase -
SG34_RS24145 (SG34_024035) 5447108..5447761 - 654 WP_044841957.1 hypothetical protein -
SG34_RS24150 (SG34_024040) 5447958..5448341 + 384 WP_044841959.1 hypothetical protein -
SG34_RS24155 (SG34_024045) 5448366..5448653 - 288 WP_044841960.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SG34_RS24160 (SG34_024050) 5448643..5448894 - 252 WP_044841961.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SG34_RS24165 (SG34_024055) 5449165..5449452 - 288 WP_044841962.1 hypothetical protein -
SG34_RS24170 (SG34_024060) 5449436..5449660 - 225 WP_152647445.1 hypothetical protein -
SG34_RS24175 (SG34_024065) 5450195..5453710 - 3516 WP_044841963.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(11-57)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11197.31 Da        Isoelectric Point: 10.5817

>T169115 WP_044841960.1 NZ_CP059733:c5448653-5448366 [Thalassomonas viridans]
MTYRLKFLPVAKKEWDKLAQPIKNQFKKKLAQRLENPHVPAARLRGYDFVYKIKLKTAGYRLAYEVIDDEVVVYVLAVGK
REKNAVYKKLVSRIE

Download         Length: 288 bp

>T169115 NZ_CP076279:c2129324-2129221 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9166.37 Da        Isoelectric Point: 4.0414

>AT169115 WP_044841961.1 NZ_CP059733:c5448894-5448643 [Thalassomonas viridans]
MRQVLADCSASISELKKNPTALINEADGAAIAILNHNKPAAYLVPAETYEWLMDMLEDYELGKIVESRRSDLSEAVEVSL
DDL

Download         Length: 252 bp

>AT169115 NZ_CP076279:2129183-2129454 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D8D030

Antitoxin

Source ID Structure
AlphaFold DB A0A0D8CZ35

References