Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 4771797..4772338 Replicon chromosome
Accession NZ_CP059733
Organism Thalassomonas viridans strain XOM25

Toxin (Protein)


Gene name parE Uniprot ID A0A0D8D9V4
Locus tag SG34_RS21095 Protein ID WP_044839704.1
Coordinates 4771797..4772099 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0D8DAK6
Locus tag SG34_RS21100 Protein ID WP_044839703.1
Coordinates 4772102..4772338 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SG34_RS21075 (SG34_020985) 4767615..4768103 - 489 Protein_4096 NADH-quinone oxidoreductase subunit NuoE -
SG34_RS21080 (SG34_020990) 4768142..4769938 - 1797 WP_236701274.1 NADH-quinone oxidoreductase subunit C/D -
SG34_RS21085 (SG34_020995) 4770018..4770656 - 639 WP_044839706.1 NADH-quinone oxidoreductase subunit B -
SG34_RS21090 (SG34_021000) 4770659..4771096 - 438 WP_044839705.1 NADH-quinone oxidoreductase subunit A -
SG34_RS21095 (SG34_021005) 4771797..4772099 - 303 WP_044839704.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SG34_RS21100 (SG34_021010) 4772102..4772338 - 237 WP_044839703.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
SG34_RS21105 (SG34_021015) 4772634..4773293 + 660 WP_044839702.1 PEP-CTERM sorting domain-containing protein -
SG34_RS21110 (SG34_021020) 4773645..4775159 + 1515 WP_053046842.1 PAS domain-containing sensor histidine kinase -
SG34_RS21115 (SG34_021025) 4775140..4775562 + 423 WP_044839701.1 response regulator -
SG34_RS21120 (SG34_021030) 4775593..4777326 + 1734 WP_044839700.1 GGDEF domain-containing response regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - galU / cheW / cheA-2 / cheY / fliA / flhG 4705485..4948623 243138


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Antitoxin ParD

(4-70)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11445.38 Da        Isoelectric Point: 9.9397

>T169114 WP_044839704.1 NZ_CP059733:c4772099-4771797 [Thalassomonas viridans]
MKAFVLTNAAKADLKRLALYTQKEWGKEQRNLYLKQFDDAFYMLADTPSVGKACDNIKAGYKKFPIGSHIVFYKKGADAY
IEVIRILHKRMDAEVNLQGL

Download         Length: 303 bp

>T169114 NZ_CP076279:c1773831-1772509 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CAGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTAACGTTATTACCCGAAAA
TGAAACCATAACGCGCCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGGCTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTTAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAATGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATGCTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGACGGTCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTAAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8684.62 Da        Isoelectric Point: 4.2465

>AT169114 WP_044839703.1 NZ_CP059733:c4772338-4772102 [Thalassomonas viridans]
MAKNTSITLGEHFDGFITSQINTGRYNSASEVIRAGLRLLEKSETKTEVLRRMLDEGEQSGIAEYSFDALIEELDAES

Download         Length: 237 bp

>AT169114 NZ_CP076279:c1774097-1773831 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACACTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D8D9V4

Antitoxin

Source ID Structure
AlphaFold DB A0A0D8DAK6

References