Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 1069217..1069761 Replicon chromosome
Accession NZ_CP059733
Organism Thalassomonas viridans strain XOM25

Toxin (Protein)


Gene name relE Uniprot ID A0A0D8D838
Locus tag SG34_RS04570 Protein ID WP_044840370.1
Coordinates 1069217..1069516 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0D8D914
Locus tag SG34_RS04575 Protein ID WP_044840371.1
Coordinates 1069504..1069761 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SG34_RS04555 (SG34_004530) 1064657..1065814 + 1158 WP_044840368.1 acyl-CoA dehydrogenase family protein -
SG34_RS04560 (SG34_004535) 1065953..1066801 + 849 WP_236701295.1 tetratricopeptide repeat protein -
SG34_RS04565 (SG34_004540) 1066993..1069155 + 2163 WP_044840369.1 winged helix-turn-helix domain-containing protein -
SG34_RS04570 (SG34_004545) 1069217..1069516 - 300 WP_044840370.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SG34_RS04575 (SG34_004550) 1069504..1069761 - 258 WP_044840371.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
SG34_RS04580 (SG34_004555) 1070121..1071176 + 1056 WP_044840372.1 radical SAM protein -
SG34_RS04585 (SG34_004560) 1071178..1072167 + 990 WP_044840373.1 hypothetical protein -
SG34_RS04590 (SG34_004565) 1072552..1073007 + 456 WP_044840374.1 hypothetical protein -
SG34_RS04595 (SG34_004570) 1073129..1073668 - 540 WP_044840375.1 peptide-methionine (S)-S-oxide reductase MsrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1063601..1078512 14911


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11629.70 Da        Isoelectric Point: 7.2769

>T169111 WP_044840370.1 NZ_CP059733:c1069516-1069217 [Thalassomonas viridans]
MVEIIWTEPALNDLNDVIEYIALQNVKAAKKLTQTIFSKIERLAFFPHSGKVPEELTMLNFKEVVVPPCRIFYRVAEDKV
YILHVMRQERDLARFLLSH

Download         Length: 300 bp

>T169111 NZ_CP076279:c1358034-1357927 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9709.28 Da        Isoelectric Point: 7.3181

>AT169111 WP_044840371.1 NZ_CP059733:c1069761-1069504 [Thalassomonas viridans]
MKVELVTTLKRQATKILADLHASKEPVLITEHGQPSAYLVDVDDYELMKKRMAILEGIARGEKAISEDRTFSHEQAQEKM
AKWLK

Download         Length: 258 bp

>AT169111 NZ_CP076279:1358087-1358148 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0D8D838

Antitoxin

Source ID Structure
AlphaFold DB A0A0D8D914

References