Detailed information of TA system TA169109

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 3276783..3277436
• Replicon: chromosome
• Accession: NZ_CP059729
• Organism: Acinetobacter baumannii strain AbCTX13

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: H0H24_RS15490
• Protein ID: WP_000607070.1
• Coordinates: 3277047..3277436 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: V5V966
• Locus tag: H0H24_RS15485
• Protein ID: WP_001288210.1
• Coordinates: 3276783..3277040 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H0H24_RS15465	3272299..3273306	+	1008	WP_000198631.1	DNA-directed RNA polymerase subunit alpha	-
H0H24_RS15470	3273325..3273702	+	378	WP_001216380.1	50S ribosomal protein L17	-
H0H24_RS15475	3273883..3275373	+	1491	WP_000415133.1	NAD(P)/FAD-dependent oxidoreductase	-
H0H24_RS15480	3275423..3276595	-	1173	WP_001190546.1	acyl-CoA dehydrogenase family protein	-
H0H24_RS15485	3276783..3277040	+	258	WP_001288210.1	succinate dehydrogenase assembly factor 2	Antitoxin
H0H24_RS15490	3277047..3277436	+	390	WP_000607070.1	hypothetical protein	Toxin
H0H24_RS15495	3278206..3279291	+	1086	WP_000049107.1	hypothetical protein	-
H0H24_RS15500	3279369..3279935	+	567	WP_000651536.1	rhombosortase	-
H0H24_RS15505	3280123..3282318	+	2196	WP_001158905.1	TRAP transporter large permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-82)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 15708.02 Da
• Isoelectric Point: 10.3599

>T169109 WP_000607070.1 NZ_CP059729:3277047-3277436 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAKIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEDHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Nucleotide

• Length: 390 bp

>T169109 NZ_CP076279:c461092-460550 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10318.77 Da
• Isoelectric Point: 4.6150

>AT169109 WP_001288210.1 NZ_CP059729:3276783-3277040 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKADPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Nucleotide

• Length: 258 bp

>AT169109 NZ_CP076279:c461387-461076 [Escherichia coli]
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACTAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Structures

Antitoxin

• AlphaFold DB: A0A7U4BQM7