Detailed information of TA system TA169080

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4198283..4199037
• Replicon: chromosome
• Accession: NZ_CP059711
• Organism: Enterobacter hormaechei strain ZHH

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A6L5EGB6
• Locus tag: H2678_RS20275
• Protein ID: WP_032669201.1
• Coordinates: 4198283..4198660 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: H2678_RS20280
• Protein ID: WP_074143921.1
• Coordinates: 4198711..4199037 (-)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H2678_RS20245	4193894..4195738	+	1845	WP_006812010.1	RNA polymerase sigma factor RpoD	-
H2678_RS20250	4195841..4196347	-	507	WP_023298636.1	G/U mismatch-specific DNA glycosylase	-
H2678_RS20260	4196650..4197498	-	849	WP_032669204.1	DUF4942 domain-containing protein	-
H2678_RS20265	4197562..4197765	-	204	WP_032669203.1	DUF957 domain-containing protein	-
H2678_RS20270	4197795..4198286	-	492	WP_032672023.1	hypothetical protein	-
H2678_RS20275	4198283..4198660	-	378	WP_032669201.1	TA system toxin CbtA family protein	Toxin
H2678_RS20280	4198711..4199037	-	327	WP_074143921.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
H2678_RS20285	4199094..4199315	-	222	WP_023567997.1	DUF987 domain-containing protein	-
H2678_RS20290	4199336..4199815	-	480	WP_032669200.1	DNA repair protein RadC	-
H2678_RS20295	4199827..4200270	-	444	WP_032669199.1	antirestriction protein	-
H2678_RS20300	4200301..4201122	-	822	WP_032669198.1	DUF945 domain-containing protein	-
H2678_RS20305	4201221..4201452	-	232	Protein_3968	DUF905 domain-containing protein	-
H2678_RS20310	4201524..4201973	-	450	WP_032669197.1	hypothetical protein	-
H2678_RS20315	4201970..4202425	-	456	WP_000754598.1	hypothetical protein	-
H2678_RS20320	4202464..4203099	-	636	WP_020837117.1	hypothetical protein	-
H2678_RS20325	4203096..4203809	-	714	WP_032669194.1	WYL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (4-103)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14157.93 Da
• Isoelectric Point: 6.2236

>T169080 WP_032669201.1 NZ_CP059711:c4198660-4198283 [Enterobacter hormaechei]
MQTQPLSSTQEATPRPSPVEIWQRLLSHLLDRHYGLTLNDTPFGNDGVIQEHIDAGISLCDAVNFIVEKYDLVRTDRRGF
NAETQSPLLSSIDILRARKATGLMTRNDYRTVTDITTGKYREVQP

Nucleotide

• Length: 378 bp

>T169080 NZ_CP059711:c4198660-4198283 [Enterobacter hormaechei]
ATGCAAACCCAACCACTATCCTCAACTCAGGAGGCTACACCACGCCCGTCACCGGTGGAGATCTGGCAACGGCTTCTGAG
CCACCTGTTGGATCGTCACTACGGTCTGACACTCAACGACACTCCGTTCGGCAACGATGGCGTGATTCAGGAGCATATCG
ACGCCGGTATCTCACTGTGCGACGCGGTGAATTTTATCGTGGAGAAATACGATCTGGTACGAACCGACCGTCGCGGTTTT
AACGCAGAAACACAGTCGCCTCTTCTCAGCAGTATCGATATTCTCCGCGCCCGCAAAGCCACCGGACTGATGACCCGAAA
CGATTACAGAACGGTGACCGACATCACCACCGGTAAATACCGGGAGGTGCAGCCATGA

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 11953.71 Da
• Isoelectric Point: 6.8397

>AT169080 WP_074143921.1 NZ_CP059711:c4199037-4198711 [Enterobacter hormaechei]
ITEPWWGLKRSITPCFGARLVQAGNRLHYLADRANITGQFSDADLRYLDQAFPLLLKQLELMLTSGELNPCHQHCVTLYA
KGLTCEADSLGSHGYVYLAIYPTPAATA

Nucleotide

• Length: 327 bp

>AT169080 NZ_CP059711:c4199037-4198711 [Enterobacter hormaechei]
ATCACTGAACCCTGGTGGGGGCTTAAACGCAGTATCACGCCCTGTTTTGGCGCACGGCTGGTACAGGCGGGCAACCGTCT
GCATTATCTCGCTGACCGGGCCAACATCACCGGACAGTTCAGCGACGCTGATTTACGGTATCTCGACCAGGCATTTCCAC
TGCTGCTCAAACAGCTTGAACTGATGCTCACCAGCGGTGAACTCAATCCCTGCCATCAGCACTGTGTCACGCTCTATGCA
AAAGGGCTGACCTGCGAGGCCGACTCCCTCGGCTCGCATGGTTACGTATACCTGGCGATTTATCCGACACCAGCGGCAAC
CGCATAA

Structures

Toxin

• AlphaFold DB: A0A6L5EGB6