Detailed information of TA system TA169079

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 4057422..4058175
• Replicon: chromosome
• Accession: NZ_CP059711
• Organism: Enterobacter hormaechei strain ZHH

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: R8WN26
• Locus tag: H2678_RS19615
• Protein ID: WP_016154457.1
• Coordinates: 4057798..4058175 (+)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: H2678_RS19610
• Protein ID: WP_162838704.1
• Coordinates: 4057422..4057748 (+)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H2678_RS19550	4052480..4052746	+	267	WP_009652486.1	hypothetical protein	-
H2678_RS19555	4052759..4053070	+	312	WP_009652410.1	hypothetical protein	-
H2678_RS19560	4053117..4053587	+	471	WP_009652431.1	hypothetical protein	-
H2678_RS19565	4053636..4054148	+	513	WP_009652395.1	DUF4234 domain-containing protein	-
H2678_RS19570	4054231..4054452	+	222	WP_009652443.1	hypothetical protein	-
H2678_RS19575	4054508..4054741	+	234	WP_009652474.1	DUF905 domain-containing protein	-
H2678_RS19580	4054845..4055663	+	819	WP_009652424.1	DUF945 domain-containing protein	-
H2678_RS19585	4055663..4055917	+	255	WP_009652519.1	hypothetical protein	-
H2678_RS19590	4055946..4056407	+	462	WP_045890390.1	antirestriction protein	-
H2678_RS19595	4056418..4056636	+	219	WP_009652503.1	hypothetical protein	-
H2678_RS19600	4056648..4057130	+	483	WP_016154455.1	DNA repair protein RadC	-
H2678_RS19605	4057144..4057365	+	222	WP_009652392.1	DUF987 domain-containing protein	-
H2678_RS19610	4057422..4057748	+	327	WP_162838704.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
H2678_RS19615	4057798..4058175	+	378	WP_016154457.1	TA system toxin CbtA family protein	Toxin
H2678_RS19620	4058172..4058663	+	492	WP_009652438.1	hypothetical protein	-
H2678_RS19625	4058693..4058896	+	204	WP_009652505.1	DUF957 domain-containing protein	-
H2678_RS19630	4058977..4059822	+	846	Protein_3834	DUF4942 domain-containing protein	-
H2678_RS19635	4059834..4060073	+	240	WP_127353160.1	hypothetical protein	-
H2678_RS19640	4060584..4061402	+	819	Protein_3836	DUF4225 domain-containing protein	-
H2678_RS19645	4061380..4061706	-	327	WP_023298582.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (4-103)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14168.19 Da
• Isoelectric Point: 9.5224

>T169079 WP_016154457.1 NZ_CP059711:4057798-4058175 [Enterobacter hormaechei]
MQTQPVPPKREVSPRPSPVAIWQRLLSHLLDRHYGLTLNDTPFGKDGVIQEHIDAGISLCDAVNFIVEKYDLVRTDRRGF
NAETQSPLLTSIDILRARKATGLMTRHSYRAVTDITTGKYREVQP

Nucleotide

• Length: 378 bp

>T169079 NZ_CP076275:c104299-103994 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 12079.85 Da
• Isoelectric Point: 6.6283

>AT169079 WP_162838704.1 NZ_CP059711:4057422-4057748 [Enterobacter hormaechei]
IAAPWWGLKRDITPCFGARLVQEGNRLHYLNDRASITGTFSDADLRHLDQAFPLLLKQLELMLLSGELNPRHQHCVTLYA
KGLICEADSLGSHGYVYLAIYPTPATTE

Nucleotide

• Length: 327 bp

>AT169079 NZ_CP076275:c104519-104301 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA

Structures

Toxin

• AlphaFold DB: R8WN26