Detailed information of TA system TA169078

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3897852..3898509
• Replicon: chromosome
• Accession: NZ_CP059711
• Organism: Enterobacter hormaechei strain ZHH

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: H2678_RS18755
• Protein ID: WP_038416677.1
• Coordinates: 3897852..3898262 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: G8LDB7
• Locus tag: H2678_RS18760
• Protein ID: WP_003863437.1
• Coordinates: 3898243..3898509 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H2678_RS18735	3893850..3895583	-	1734	WP_038416675.1	single-stranded-DNA-specific exonuclease RecJ	-
H2678_RS18740	3895589..3896302	-	714	WP_022649304.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
H2678_RS18745	3896331..3897227	-	897	WP_003863442.1	site-specific tyrosine recombinase XerD	-
H2678_RS18750	3897329..3897850	+	522	WP_023306886.1	flavodoxin FldB	-
H2678_RS18755	3897852..3898262	-	411	WP_038416677.1	protein YgfX	Toxin
H2678_RS18760	3898243..3898509	-	267	WP_003863437.1	FAD assembly factor SdhE	Antitoxin
H2678_RS18765	3898804..3899784	+	981	WP_038416679.1	tRNA-modifying protein YgfZ	-
H2678_RS18770	3899870..3900529	-	660	WP_022649307.1	hemolysin III family protein	-
H2678_RS18775	3900796..3901527	+	732	WP_022649308.1	MurR/RpiR family transcriptional regulator	-
H2678_RS18780	3901644..3903077	+	1434	WP_038416681.1	6-phospho-beta-glucosidase BglA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16337.20 Da
• Isoelectric Point: 11.4775

>T169078 WP_038416677.1 NZ_CP059711:c3898262-3897852 [Enterobacter hormaechei]
VVLWQSDLRVSWRSQWMSLLLHGLVAAMVLLVPWPLSYTPLWLLLLSFVVFDSVRSQRRINSRQGEIKLLMDSRLRWQGK
EWEMIGTPWMLNTGMMLRLRRVEDNRRQHLWLAADSMDPAEWRDLRRLIVQQPTQE

Nucleotide

• Length: 411 bp

>T169078 NZ_CP076275:58718-59116 [Escherichia coli]
ATGCTGAAGTTTATGCTCGATACCAACATCTGCATTTTTACGATAAAGAACAAACCCGCCAGTGTCAGGGAACGTTTTAA
CCTGAACCAGGGGAGAATGTGCATCAGTTCGGTCACTCTGATGGAGCTGATATATGGTGCAGAAAAAAGCCAGATGCCTG
AACGTAATCTCGCTGTGATCGAGGGATTTGTTTCCCGCATTGACGTTCTGGATTACGACGCTGCTGCTGCCACACACACC
GGCCAGATAAGAGCAGAACTTGCCCGTCAGGCACGCCCTGTCGGGCCATTTGATCAAATGATCGCAGGTCATGCCCGCAG
TCGGGGACTGATTATTGTGACTAATAACACCCGGGAATTTGAACGTGTGGGCGGCCTGAGAATTGAAGACTGGAGTTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10526.96 Da
• Isoelectric Point: 4.8310

>AT169078 WP_003863437.1 NZ_CP059711:c3898509-3898243 [Enterobacter hormaechei]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Nucleotide

• Length: 267 bp

>AT169078 NZ_CP076275:58491-58718 [Escherichia coli]
ATGGAAACCACCGTATTTCTCAGCAACCGCAGCCAGGCGGTCAGACTGCCAAAAGCGGTTGCATTGCCGGAAAACGTAAA
ACGCGTTGAAGTGATTGCTGTCGGACGAACCCGAATCATTACGCCTGCCGGAGAGACATGGGACGAATGGTTCGACGGAA
ACAGTGTCAGCGCTGATTTTATGGATAACAGGGAACAGCCTGGTATGCAGGAAAGGGAGTCATTCTGA

Structures

Antitoxin

• AlphaFold DB: A0A837F8P5