Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 100122..100840 | Replicon | chromosome |
| Accession | NZ_CP059711 | ||
| Organism | Enterobacter hormaechei strain ZHH | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A822WUK4 |
| Locus tag | H2678_RS00505 | Protein ID | WP_071605960.1 |
| Coordinates | 100122..100442 (-) | Length | 107 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | H2678_RS00510 | Protein ID | WP_044599779.1 |
| Coordinates | 100484..100840 (-) | Length | 119 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H2678_RS00465 | 95684..96163 | + | 480 | WP_022646606.1 | hypothetical protein | - |
| H2678_RS00470 | 96406..97287 | + | 882 | WP_038415011.1 | helix-turn-helix domain-containing protein | - |
| H2678_RS00475 | 97352..97651 | - | 300 | WP_038415012.1 | XRE family transcriptional regulator | - |
| H2678_RS00480 | 97648..97998 | - | 351 | WP_038415013.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| H2678_RS00485 | 98266..98518 | - | 253 | Protein_96 | DNA-binding protein | - |
| H2678_RS00490 | 98621..98962 | - | 342 | WP_038415015.1 | SymE family type I addiction module toxin | - |
| H2678_RS00495 | 99088..99279 | + | 192 | WP_038416963.1 | toxin-antitoxin system HicB family antitoxin | - |
| H2678_RS00500 | 99285..99911 | - | 627 | WP_051979808.1 | hypothetical protein | - |
| H2678_RS00505 | 100122..100442 | - | 321 | WP_071605960.1 | TA system toxin CbtA family protein | Toxin |
| H2678_RS00510 | 100484..100840 | - | 357 | WP_044599779.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| H2678_RS00515 | 100872..101093 | - | 222 | WP_057696015.1 | DUF987 family protein | - |
| H2678_RS00520 | 101102..101572 | - | 471 | WP_023305179.1 | DNA repair protein RadC | - |
| H2678_RS00525 | 101642..102463 | - | 822 | WP_044599778.1 | DUF945 domain-containing protein | - |
| H2678_RS00530 | 102906..103097 | - | 192 | WP_071605959.1 | hypothetical protein | - |
| H2678_RS00535 | 103156..103995 | - | 840 | WP_052735741.1 | hypothetical protein | - |
| H2678_RS00540 | 104055..104489 | - | 435 | WP_044599777.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 97648..122218 | 24570 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 107 a.a. Molecular weight: 12227.83 Da Isoelectric Point: 6.3229
>T169067 WP_071605960.1 NZ_CP059711:c100442-100122 [Enterobacter hormaechei]
MHISTVPKTVTVSSRLSPVQVWQKLLTYILEHHYGLTINDTPFSNDTTIQEHIEAGVNLTDAVNFLVERFELVRIDQKSF
SWQDQEPWITSLDVHRAQSNLGLKRP
MHISTVPKTVTVSSRLSPVQVWQKLLTYILEHHYGLTINDTPFSNDTTIQEHIEAGVNLTDAVNFLVERFELVRIDQKSF
SWQDQEPWITSLDVHRAQSNLGLKRP
Download Length: 321 bp
>T169067 NZ_CP076274:3634330-3634794 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTTTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTTTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA
Antitoxin
Download Length: 119 a.a. Molecular weight: 13081.91 Da Isoelectric Point: 7.7487
>AT169067 WP_044599779.1 NZ_CP059711:c100840-100484 [Enterobacter hormaechei]
MQSTTISGTSAKNTSCLQWGLKRNITPCFGARLVQKGKRLYFLADRAGFNGSFSDAEALSLDQAFPLMVKQLERMLTTGE
LDPHNQHCVTLHHNGLTCEADTLGSYGYVYIAIYPHQL
MQSTTISGTSAKNTSCLQWGLKRNITPCFGARLVQKGKRLYFLADRAGFNGSFSDAEALSLDQAFPLMVKQLERMLTTGE
LDPHNQHCVTLHHNGLTCEADTLGSYGYVYIAIYPHQL
Download Length: 357 bp
>AT169067 NZ_CP076274:3633995-3634330 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|