Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 434167..434816 Replicon chromosome
Accession NZ_CP059676
Organism Flaviflexus sp. dk850

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag H2O75_RS02060 Protein ID WP_182172969.1
Coordinates 434397..434816 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag H2O75_RS02055 Protein ID WP_182172966.1
Coordinates 434167..434400 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H2O75_RS02030 429967..431124 - 1158 WP_182172957.1 DNA recombination protein RmuC -
H2O75_RS02035 431277..432356 + 1080 WP_182172960.1 redox-regulated ATPase YchF -
H2O75_RS02040 432390..432674 + 285 WP_182172963.1 type II toxin-antitoxin system RelE/ParE family toxin -
H2O75_RS02045 432643..432969 + 327 WP_182174838.1 HigA family addiction module antidote protein -
H2O75_RS02050 433004..433455 + 452 Protein_393 GNAT family N-acetyltransferase -
H2O75_RS02055 434167..434400 + 234 WP_182172966.1 toxin-antitoxin system Antitoxin
H2O75_RS02060 434397..434816 + 420 WP_182172969.1 type II toxin-antitoxin system VapC family toxin Toxin
H2O75_RS02065 435286..435645 + 360 WP_182172972.1 VOC family protein -
H2O75_RS02070 435709..436188 + 480 WP_182172975.1 DUF2975 domain-containing protein -
H2O75_RS02075 436188..436406 + 219 WP_182172978.1 helix-turn-helix transcriptional regulator -
H2O75_RS02080 436583..437335 + 753 WP_182174841.1 heliorhodopsin HeR -
H2O75_RS02085 437421..437861 + 441 WP_182172981.1 hypothetical protein -
H2O75_RS02090 437868..438492 - 625 Protein_401 PIG-L family deacetylase -
H2O75_RS02095 438539..439759 - 1221 WP_182172985.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-130)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15007.09 Da        Isoelectric Point: 4.2984

>T169057 WP_182172969.1 NZ_CP059676:434397-434816 [Flaviflexus sp. dk850]
MIVLDTSVISEVFRPTPDPGVLAWLESLTGDVAITTITLAELLAGVRRLPAGRRKSDLELALDAALEPYRNTRSLLAFDD
ASAAEYAEVLLAREQAELPISTPDAQIAAICRANGAICATRNERDFAETGVQVLSPWTR

Download         Length: 420 bp

>T169057 NZ_CP076274:c1536851-1536657 [Escherichia coli]
ATGCGGTATGAAAAAGTCAAACCATGCCCTTTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
CGCGAAGTGTAACGGATGCGAATCCCGAACCGGCTATGGTGGAAGTGAAAAAGAAGCACTCGAACGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8387.51 Da        Isoelectric Point: 5.1023

>AT169057 WP_182172966.1 NZ_CP059676:434167-434400 [Flaviflexus sp. dk850]
MASIVVRGLDESVKNRLAAQAKEHGRSMEAEVREILTRASSPPHIGIALMGFARDVGEVEELQIPARSDTARAVDFE

Download         Length: 234 bp

>AT169057 NZ_CP076274:1536480-1536658 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTCCCTGA
GAGCATTTTTTCGCATTCTGATTTGGTTAACTTTGTTTTTGAGTACCTTGTCCAGTTAGTAGGAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References