Detailed information of TA system TA169056

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC(toxin)
• Location: 1801551..1802197
• Replicon: chromosome
• Accession: NZ_CP059675
• Organism: Schaalia sp. JY-X169

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: H2O65_RS08005
• Protein ID: WP_182141200.1
• Coordinates: 1801551..1801940 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: H2O65_RS08010
• Protein ID: WP_182141201.1
• Coordinates: 1801937..1802197 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H2O65_RS07990	1796747..1797928	+	1182	WP_182141198.1	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	-
H2O65_RS07995	1797948..1798724	-	777	WP_182141199.1	fumarylacetoacetate hydrolase family protein	-
H2O65_RS08000	1798837..1801539	+	2703	WP_182142737.1	DUF3516 domain-containing protein	-
H2O65_RS08005	1801551..1801940	-	390	WP_182141200.1	type II toxin-antitoxin system VapC family toxin	Toxin
H2O65_RS08010	1801937..1802197	-	261	WP_182141201.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
H2O65_RS08015	1802244..1803308	-	1065	WP_182141202.1	lipoate--protein ligase family protein	-
H2O65_RS08020	1803481..1805358	+	1878	WP_182141203.1	dihydroxy-acid dehydratase	-
H2O65_RS08025	1805448..1806485	+	1038	WP_182141204.1	LCP family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-123)

Antitoxin

• Antitoxin VapB-like (1-85)

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 13966.60 Da
• Isoelectric Point: 4.6864

>T169056 WP_182141200.1 NZ_CP059675:c1801940-1801551 [Schaalia sp. JY-X169]
VIIDTSAIIAVLRSEDESERIAEALASTSDLRISAATYVELFAVLSRSRDHTIAARRLLDDLGATVEPFDHAQAKIASSA
YVQYGRGSGHRAGLNLGDTYSYALAWITGQELLFVGDDFSHTDVLPALR

Nucleotide

• Length: 390 bp

>T169056 NZ_CP076274:c1357960-1357853 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9416.43 Da
• Isoelectric Point: 4.6768

>AT169056 WP_182141201.1 NZ_CP059675:c1802197-1801937 [Schaalia sp. JY-X169]
MSLNIKNQETHAKVRRLAELTGASQTAAVDDAVERRLRELGADPNLDRRAEVRAALARFAAAFSDEEAHALQEAQEALYD
SEGLPV

Nucleotide

• Length: 261 bp

>AT169056 NZ_CP076274:1358007-1358073 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT