Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 1426198..1426718 Replicon chromosome
Accession NZ_CP059675
Organism Schaalia sp. JY-X169

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag H2O65_RS06295 Protein ID WP_182140920.1
Coordinates 1426428..1426718 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID -
Locus tag H2O65_RS06290 Protein ID WP_182140919.1
Coordinates 1426198..1426431 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H2O65_RS06275 1422108..1423031 - 924 WP_182140916.1 restriction endonuclease -
H2O65_RS06280 1423028..1424596 - 1569 WP_182140917.1 type I restriction-modification system subunit M -
H2O65_RS06285 1424819..1425898 + 1080 WP_182140918.1 restriction endonuclease -
H2O65_RS06290 1426198..1426431 + 234 WP_182140919.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
H2O65_RS06295 1426428..1426718 + 291 WP_182140920.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H2O65_RS06300 1426754..1427089 - 336 WP_182142696.1 PGPGW domain-containing protein -
H2O65_RS06305 1427231..1427791 + 561 WP_182140921.1 dihydrofolate reductase family protein -
H2O65_RS06310 1427788..1428945 - 1158 WP_182140922.1 MFS transporter -
H2O65_RS06315 1429028..1429669 + 642 WP_182140923.1 hypothetical protein -
H2O65_RS06320 1429677..1430234 - 558 WP_182140924.1 DNA polymerase III subunit epsilon -
H2O65_RS06325 1430382..1430723 + 342 WP_182140925.1 DUF4342 domain-containing protein -
H2O65_RS06330 1430764..1431195 + 432 WP_182140926.1 DUF1269 domain-containing protein -
H2O65_RS06335 1431198..1431458 + 261 WP_182140927.1 SHOCT domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin

Antitoxin ParD

(1-76)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11286.78 Da        Isoelectric Point: 10.1868

>T169055 WP_182140920.1 NZ_CP059675:1426428-1426718 [Schaalia sp. JY-X169]
VSRYRLTPAAQRDLSSIWDFTQGRWDARQAETYVTEIRAALERIADNPGRGRTCDEIRVGYRRYSIGSHLIFYVKRPDGV
DVIRILHQRMDPTRHL

Download         Length: 291 bp

>T169055 NZ_CP076274:c1357425-1357318 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8354.29 Da        Isoelectric Point: 4.5338

>AT169055 WP_182140919.1 NZ_CP059675:1426198-1426431 [Schaalia sp. JY-X169]
MAQNTSISLDDHFSGFLSREVSSGRYRSASEVVRAGLRLLEDQETQMAALRAALVTGEESGAPEVFDFEAFIAAKKS

Download         Length: 234 bp

>AT169055 NZ_CP076274:1357472-1357538 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References