Detailed information of TA system TA169048

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 2058095..2058651
• Replicon: chromosome
• Accession: NZ_CP059591
• Organism: Xanthomonas oryzae pv. oryzae strain IXO221

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: IXO221_RS09590
• Protein ID: WP_229001948.1
• Coordinates: 2058400..2058651 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A854CIX2
• Locus tag: IXO221_RS09585
• Protein ID: WP_011408759.1
• Coordinates: 2058095..2058373 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IXO221_RS09565 (IXO221_009645)	2053212..2053769	-	558	WP_011259349.1	DNA-3-methyladenine glycosylase	-
IXO221_RS09570 (IXO221_009650)	2053919..2054884	-	966	WP_109181970.1	IS1595-like element ISXo5 family transposase	-
IXO221_RS09575 (IXO221_009655)	2055465..2056649	+	1185	WP_117231633.1	IS256 family transposase	-
IXO221_RS09580 (IXO221_009665)	2057513..2057899	+	387	WP_205421001.1	hypothetical protein	-
IXO221_RS09585 (IXO221_009670)	2058095..2058373	+	279	WP_011408759.1	CopG family ribbon-helix-helix protein	Antitoxin
IXO221_RS09590 (IXO221_009675)	2058400..2058651	+	252	WP_229001948.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IXO221_RS09595	2058912..2059109	+	198	WP_004541336.1	hypothetical protein	-
IXO221_RS09600 (IXO221_009685)	2059178..2059432	+	255	WP_223293127.1	hypothetical protein	-
IXO221_RS09605	2059649..2059768	+	120	Protein_1839	IS3 family transposase	-
IXO221_RS09615 (IXO221_009700)	2060296..2060697	-	402	WP_011259345.1	H-NS family nucleoid-associated regulatory protein	-
IXO221_RS09620 (IXO221_009705)	2060919..2061095	+	177	Protein_1841	DUF3606 domain-containing protein	-
IXO221_RS09625 (IXO221_009715)	2061377..2061714	+	338	Protein_1842	ATP-dependent DNA ligase	-
IXO221_RS09630 (IXO221_009720)	2061790..2062881	-	1092	WP_041182166.1	ribonuclease D	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-81)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9603.92 Da
• Isoelectric Point: 9.9718

>T169048 WP_229001948.1 NZ_CP059591:2058400-2058651 [Xanthomonas oryzae pv. oryzae]
MLRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLSEQYREWLIDFGDSGYVARYRFDGDTVTILAVRHQKE
AGY

Nucleotide

• Length: 252 bp

>T169048 NZ_CP076272:4843720-4844667 [Escherichia coli]
ATGGATGATTTAACCACTCTTTTTTCTGAAGTGGCTGACGCGCTTGGTATTGAGTCTGTCGCAATTGTGGAAAAAGATCA
CTATATCGTTGAGCTTTTGCAATTGCTTAAACCTCTGGTGTTCGATACTCATCAATTGGTGTTTGCCGGAGGAACCGCTC
TGGCAAAATCAGGTGTCGCACTTAATCGCATGTCGGAAGATGTGGATATCAAACTGGTGCCTAAGGATGCATTTCAGGCA
CTTTCCCGCACTCAGCGAAAAAATACCCGTAAAGAAATTGTTCAGGCAGTTTCCAGTGCAATAGCTTCATCGGGTGTGTT
CAATTTTGATGATGATTACCCAAAAGTGACGCGGGATGAATATCGTTATAATGACATACCTGTTCGTTATCCACAGCGAG
TAGTGCAGGCACCTTGTTTGCGTCCTTTTATCCGGCTGGAACTGATGGAAGCGAAGTTACTGGAGCCTTCTGAATTACGG
GATATTCATTCACTGGTAACAGGGATCACGGGAAAAGCGGCTATTGTTTCAGCGTTTCCATGCGCAACTATCATTAGCAC
ACAGGCAGAAAAGCTGGTGGCGATGTTACGTCGTACTGCGGCAGTTGTGCGAGATGTTGAGCGATTTGATGATGCATCGC
TGGTACGTCATATCTACGATACAAACTGTATTGTTGAGACGAGTCATGTTGATATGAGTCTGCTCGTTGATTTTGTTCAA
CAAACTATTGAGCAGGACATTCAGCGTTACGGCAACCAGTACACGCAGTTTTGCGCGTCTCCAGTTGATGAGCTAAAAAT
GGGACTGGATGAGTTGGCGAACAATCCTCTCTACCAGATGCGCTATCAGCAGTTTGTTTCGCCAATGGTGTATGGAGAGC
GAAAGATCACATGGGATGAGGCTTACTCCAGGTTTAGGAGCTTAGCGCTAGCCATCCTGAATGCTTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10826.11 Da
• Isoelectric Point: 4.9736

>AT169048 WP_011408759.1 NZ_CP059591:2058095-2058373 [Xanthomonas oryzae pv. oryzae]
MVTATSIKLDDELKGRVQHLAESRRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT169048 NZ_CP076272:4843332-4843727 [Escherichia coli]
ATGACGATAAAAGCACGCATTCAGTCACGACTGAAACGTTCTAAACGTTACGTATTCACTCGTGACGACTTTAAAGATAT
TGCAGGCTACGATCAGGTTGGTCGGGTATTGCGCGAGCTTGTCAGGGAAGGGCAACTGTTGAAGGTTGGTTATGGCGTGT
ATACCAAAGCACGGCGGAACGGTATTACAGGCAAGGTAATGCCAGCGGCTCCCGGAGGCTCTTCAGCGGTGATTGTCGAA
ACGCTGGAACGCCTGAAAGTACGCTATCGTTTTGCTGGCGCAACGCAGGCATACAATAGCGGTACTTCTACGCAGATCCC
AGCTTCACCCGAGATAAAAACCCCCCGGCGTTTTAAACGCGTATTATCTGTAGGGAACAGCAGATTAAATGGATGA

Structures

Antitoxin

• AlphaFold DB: A0A854CIX2