Detailed information of TA system TA169038

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 2985518..2986074
• Replicon: chromosome
• Accession: NZ_CP059589
• Organism: Xanthomonas oryzae pv. oryzae strain IXO675

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: IXO675_RS13865
• Protein ID: WP_229001948.1
• Coordinates: 2985518..2985769 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A854CIX2
• Locus tag: IXO675_RS13870
• Protein ID: WP_011408759.1
• Coordinates: 2985796..2986074 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IXO675_RS13820 (IXO675_013770)	2981288..2982379	+	1092	WP_011408756.1	ribonuclease D	-
IXO675_RS13825 (IXO675_013775)	2982476..2982792	-	317	Protein_2647	ATP-dependent DNA ligase	-
IXO675_RS13830 (IXO675_013785)	2983074..2983250	-	177	Protein_2648	DUF3606 domain-containing protein	-
IXO675_RS13835 (IXO675_013790)	2983472..2983873	+	402	WP_011259345.1	H-NS family nucleoid-associated regulatory protein	-
IXO675_RS13845	2984304..2984432	-	129	WP_012444694.1	hypothetical protein	-
IXO675_RS13850	2984401..2984520	-	120	Protein_2651	IS3 family transposase	-
IXO675_RS13855 (IXO675_013805)	2984737..2984991	-	255	WP_223293127.1	hypothetical protein	-
IXO675_RS13860	2985060..2985257	-	198	WP_153296741.1	hypothetical protein	-
IXO675_RS13865 (IXO675_013815)	2985518..2985769	-	252	WP_229001948.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IXO675_RS13870 (IXO675_013820)	2985796..2986074	-	279	WP_011408759.1	CopG family ribbon-helix-helix protein	Antitoxin
IXO675_RS13875 (IXO675_013825)	2986270..2986614	-	345	WP_198912817.1	hypothetical protein	-
IXO675_RS13880 (IXO675_013835)	2987520..2988704	-	1185	WP_011408397.1	IS256-like element IS1113 family transposase	-
IXO675_RS13885 (IXO675_013840)	2989285..2990250	+	966	Protein_2658	IS1595-like element ISXo5 family transposase	-
IXO675_RS13890 (IXO675_013845)	2990400..2990957	+	558	WP_011259349.1	DNA-3-methyladenine glycosylase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-81)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9603.92 Da
• Isoelectric Point: 9.9718

>T169038 WP_229001948.1 NZ_CP059589:c2985769-2985518 [Xanthomonas oryzae pv. oryzae]
MLRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLSEQYREWLIDFGDSGYVARYRFDGDTVTILAVRHQKE
AGY

Nucleotide

• Length: 252 bp

>T169038 NZ_CP076272:c2307355-2307104 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATATAACTCCCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10826.11 Da
• Isoelectric Point: 4.9736

>AT169038 WP_011408759.1 NZ_CP059589:c2986074-2985796 [Xanthomonas oryzae pv. oryzae]
MVTATSIKLDDELKGRVQHLAESRRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT169038 NZ_CP076272:c2307107-2306853 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTTTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAGCATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Structures

Antitoxin

• AlphaFold DB: A0A854CIX2