Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) rlegTA/AbiEii-AbiEi
Location 1548278..1549797 Replicon chromosome
Accession NZ_CP059586
Organism Xanthomonas oryzae pv. oryzae strain IXO639

Toxin (Protein)


Gene name rlegT Uniprot ID A0A0K0GMB6
Locus tag IXO639_RS07370 Protein ID WP_011259680.1
Coordinates 1548874..1549797 (+) Length 308 a.a.

Antitoxin (Protein)


Gene name rlegA Uniprot ID A0A854CLN1
Locus tag IXO639_RS07365 Protein ID WP_011409027.1
Coordinates 1548278..1548877 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IXO639_RS07330 (IXO639_007375) 1543946..1544482 - 537 WP_024743012.1 lipocalin family protein -
IXO639_RS07340 1544859..1545233 - 375 WP_237384745.1 hypothetical protein -
IXO639_RS07345 1545214..1545504 - 291 WP_011409031.1 hypothetical protein -
IXO639_RS07350 (IXO639_007395) 1546003..1547034 + 1032 WP_263108693.1 IS630 family transposase -
IXO639_RS07355 (IXO639_007400) 1547016..1547591 - 576 WP_080493559.1 BrxE family protein -
IXO639_RS07360 (IXO639_007405) 1547623..1547913 - 291 WP_233282844.1 FaeA/PapI family transcriptional regulator -
IXO639_RS07365 (IXO639_007410) 1548278..1548877 + 600 WP_011409027.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
IXO639_RS07370 (IXO639_007415) 1548874..1549797 + 924 WP_011259680.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
IXO639_RS07375 1549877..1550347 - 471 WP_228329666.1 helix-turn-helix domain-containing protein -
IXO639_RS07380 (IXO639_007430) 1550813..1551055 + 243 WP_011259679.1 hypothetical protein -
IXO639_RS07385 (IXO639_007435) 1551480..1551989 + 510 WP_011259678.1 hypothetical protein -
IXO639_RS07390 (IXO639_007440) 1552006..1552538 - 533 Protein_1409 protein N-lysine methyltransferase family protein -
IXO639_RS07395 (IXO639_007445) 1552558..1553934 - 1377 Protein_1410 IS5 family transposase -
IXO639_RS07400 (IXO639_007450) 1554046..1554198 - 153 Protein_1411 SAM-dependent methyltransferase -
IXO639_RS07405 1554333..1554554 + 222 WP_154215184.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(41-269)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(7-52)


Sequences

Toxin        


Download         Length: 308 a.a.        Molecular weight: 34114.16 Da        Isoelectric Point: 5.4588

>T169022 WP_011259680.1 NZ_CP059586:1548874-1549797 [Xanthomonas oryzae pv. oryzae]
MNEPDKSRRTVAASVRARLLNKARAERLDFNLLLTRYALERVLYRLSVSEQQGQFLLKGALLFDIWFDIPHRPTHDADLL
GFGSTEIPHLEDLFRRISQIASDDGIVFQADSVKAAEIRKEANYAGVRVTMIGLLDGARCTVQIDIGFGDAVTPGPDNVQ
YPVILDGMPQPQLRVYPRYTVVAEKLEAMVKLGILNSRMKDYFDLWVLAGHSDFDGAVLATAIRATFECRGTAIPPGAPL
GLTDEFGLDEQKTKQWQAFLRKNTLEPMPLTTVIEALREFVLPVLAALAAGEGFDRQWRAGAGWDAA

Download         Length: 924 bp

>T169022 NZ_CP076270:4611947-4612120 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22037.74 Da        Isoelectric Point: 10.1240

>AT169022 WP_011409027.1 NZ_CP059586:1548278-1548877 [Xanthomonas oryzae pv. oryzae]
MDTTVDKLLELVRTRGLLRPHDLAPLGIPRVALTRAVRRGQLERVGRGLYGLVARPVSAHGTLAEVARRVPKGVVCLLSA
LRVHDLTTQAPFEVWLAIDNKAAAPKLDYPPLRLVRFSGPALSEGVEEHVVDGVPVHVTSVAKTVADCFKYRNKIGIDVA
LEALREAWVARRMTSDEIWHYAKIDRVANVMRPYLESLA

Download         Length: 600 bp

>AT169022 NZ_CP076270:4611623-4611919 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CTTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K0GMB6

Antitoxin

Source ID Structure
AlphaFold DB A0A854CLN1

References