Detailed information of TA system TA169017

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 1025150..1025706
• Replicon: chromosome
• Accession: NZ_CP059585
• Organism: Xanthomonas oryzae pv. oryzae strain IXO630

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: IXO630_RS04670
• Protein ID: WP_229001948.1
• Coordinates: 1025150..1025401 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A854CIX2
• Locus tag: IXO630_RS04675
• Protein ID: WP_011408759.1
• Coordinates: 1025428..1025706 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IXO630_RS04620 (IXO630_004610)	1020920..1022011	+	1092	WP_075239568.1	ribonuclease D	-
IXO630_RS04625 (IXO630_004615)	1022108..1022424	-	317	Protein_884	ATP-dependent DNA ligase	-
IXO630_RS04630 (IXO630_004625)	1022706..1022882	-	177	Protein_885	DUF3606 domain-containing protein	-
IXO630_RS04635 (IXO630_004630)	1023104..1023505	+	402	WP_011259345.1	H-NS family nucleoid-associated regulatory protein	-
IXO630_RS04645	1023936..1024064	-	129	WP_012444694.1	hypothetical protein	-
IXO630_RS04650	1024033..1024152	-	120	Protein_888	IS3 family transposase	-
IXO630_RS04655 (IXO630_004645)	1024369..1024623	-	255	WP_223293127.1	hypothetical protein	-
IXO630_RS04660	1024692..1024826	-	135	WP_011051575.1	hypothetical protein	-
IXO630_RS04665 (IXO630_004650)	1024819..1025073	-	255	WP_198912806.1	hypothetical protein	-
IXO630_RS04670 (IXO630_004655)	1025150..1025401	-	252	WP_229001948.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IXO630_RS04675 (IXO630_004660)	1025428..1025706	-	279	WP_011408759.1	CopG family ribbon-helix-helix protein	Antitoxin
IXO630_RS04680 (IXO630_004665)	1025902..1026246	-	345	WP_199285675.1	hypothetical protein	-
IXO630_RS04685 (IXO630_004675)	1026723..1027958	+	1236	WP_012443979.1	ISL3-like element ISXoo13 family transposase	-
IXO630_RS04690 (IXO630_004680)	1028287..1029522	-	1236	WP_044756360.1	ISL3-like element ISXoo13 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-81)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9603.92 Da
• Isoelectric Point: 9.9718

>T169017 WP_229001948.1 NZ_CP059585:c1025401-1025150 [Xanthomonas oryzae pv. oryzae]
MLRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLSEQYREWLIDFGDSGYVARYRFDGDTVTILAVRHQKE
AGY

Nucleotide

• Length: 252 bp

>T169017 NZ_CP076270:c3178309-3177902 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10826.11 Da
• Isoelectric Point: 4.9736

>AT169017 WP_011408759.1 NZ_CP059585:c1025706-1025428 [Xanthomonas oryzae pv. oryzae]
MVTATSIKLDDELKGRVQHLAESRRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT169017 NZ_CP076270:c3178556-3178290 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: A0A854CIX2