Detailed information of TA system TA169015

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 3070685..3071241
• Replicon: chromosome
• Accession: NZ_CP059584
• Organism: Xanthomonas oryzae pv. oryzae strain IXO493

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: IXO493_RS14490
• Protein ID: WP_229001948.1
• Coordinates: 3070685..3070936 (-)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A854CIX2
• Locus tag: IXO493_RS14495
• Protein ID: WP_011408759.1
• Coordinates: 3070963..3071241 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IXO493_RS14440 (IXO493_014405)	3066455..3067546	+	1092	WP_075239568.1	ribonuclease D	-
IXO493_RS14445 (IXO493_014410)	3067643..3067959	-	317	Protein_2749	ATP-dependent DNA ligase	-
IXO493_RS14450 (IXO493_014420)	3068241..3068417	-	177	Protein_2750	DUF3606 domain-containing protein	-
IXO493_RS14455 (IXO493_014425)	3068639..3069040	+	402	WP_011259345.1	H-NS family nucleoid-associated regulatory protein	-
IXO493_RS14465	3069471..3069599	-	129	WP_012444694.1	hypothetical protein	-
IXO493_RS14470	3069568..3069687	-	120	Protein_2753	IS3 family transposase	-
IXO493_RS14475 (IXO493_014440)	3069904..3070158	-	255	WP_223293127.1	hypothetical protein	-
IXO493_RS14480	3070227..3070361	-	135	WP_011051575.1	hypothetical protein	-
IXO493_RS14485 (IXO493_014445)	3070354..3070608	-	255	WP_198912806.1	hypothetical protein	-
IXO493_RS14490 (IXO493_014450)	3070685..3070936	-	252	WP_229001948.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IXO493_RS14495 (IXO493_014455)	3070963..3071241	-	279	WP_011408759.1	CopG family ribbon-helix-helix protein	Antitoxin
IXO493_RS14500 (IXO493_014460)	3071437..3071781	-	345	WP_199285675.1	hypothetical protein	-
IXO493_RS14505 (IXO493_014470)	3072258..3073493	+	1236	WP_012443979.1	ISL3-like element ISXoo13 family transposase	-
IXO493_RS14510 (IXO493_014475)	3073822..3075057	-	1236	WP_044756360.1	ISL3-like element ISXoo13 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-81)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9603.92 Da
• Isoelectric Point: 9.9718

>T169015 WP_229001948.1 NZ_CP059584:c3070936-3070685 [Xanthomonas oryzae pv. oryzae]
MLRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLSEQYREWLIDFGDSGYVARYRFDGDTVTILAVRHQKE
AGY

Nucleotide

• Length: 252 bp

>T169015 NZ_CP076270:c2750992-2750594 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTGATTGAAGGTTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGATTGGAGCTAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10826.11 Da
• Isoelectric Point: 4.9736

>AT169015 WP_011408759.1 NZ_CP059584:c3071241-3070963 [Xanthomonas oryzae pv. oryzae]
MVTATSIKLDDELKGRVQHLAESRRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT169015 NZ_CP076270:c2751219-2750992 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAGGATGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTCTGA

Structures

Antitoxin

• AlphaFold DB: A0A854CIX2