Detailed information of TA system TA169003

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 4435783..4436339
• Replicon: chromosome
• Accession: NZ_CP059581
• Organism: Xanthomonas oryzae pv. oryzae strain IXO98

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: IXO98_RS20590
• Protein ID: WP_229001948.1
• Coordinates: 4436088..4436339 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A854CIX2
• Locus tag: IXO98_RS20585
• Protein ID: WP_011408759.1
• Coordinates: 4435783..4436061 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IXO98_RS20565 (IXO98_020580)	4430901..4431458	-	558	WP_011259349.1	DNA-3-methyladenine glycosylase	-
IXO98_RS20570 (IXO98_020585)	4431608..4432572	-	965	Protein_3932	IS1595-like element ISXo5 family transposase	-
IXO98_RS20575 (IXO98_020590)	4433153..4434337	+	1185	WP_117231633.1	IS256 family transposase	-
IXO98_RS20580 (IXO98_020600)	4435201..4435587	+	387	WP_205421001.1	hypothetical protein	-
IXO98_RS20585 (IXO98_020605)	4435783..4436061	+	279	WP_011408759.1	CopG family ribbon-helix-helix protein	Antitoxin
IXO98_RS20590 (IXO98_020610)	4436088..4436339	+	252	WP_229001948.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IXO98_RS20595 (IXO98_020615)	4436416..4436670	+	255	WP_198912806.1	hypothetical protein	-
IXO98_RS20600	4436663..4436797	+	135	WP_011051575.1	hypothetical protein	-
IXO98_RS20605 (IXO98_020620)	4436866..4437120	+	255	WP_223293127.1	hypothetical protein	-
IXO98_RS20610	4437337..4437456	+	120	Protein_3940	IS3 family transposase	-
IXO98_RS20615	4437425..4437553	+	129	WP_012444694.1	hypothetical protein	-
IXO98_RS20625 (IXO98_020635)	4437984..4438385	-	402	WP_011259345.1	H-NS family nucleoid-associated regulatory protein	-
IXO98_RS20630 (IXO98_020640)	4438607..4438783	+	177	Protein_3943	DUF3606 domain-containing protein	-
IXO98_RS20635 (IXO98_020650)	4439065..4439402	+	338	Protein_3944	ATP-dependent DNA ligase	-
IXO98_RS20640 (IXO98_020655)	4439478..4440569	-	1092	WP_041182166.1	ribonuclease D	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-81)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9603.92 Da
• Isoelectric Point: 9.9718

>T169003 WP_229001948.1 NZ_CP059581:4436088-4436339 [Xanthomonas oryzae pv. oryzae]
MLRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLSEQYREWLIDFGDSGYVARYRFDGDTVTILAVRHQKE
AGY

Nucleotide

• Length: 252 bp

>T169003 NZ_CP076269:86457-86762 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10826.11 Da
• Isoelectric Point: 4.9736

>AT169003 WP_011408759.1 NZ_CP059581:4435783-4436061 [Xanthomonas oryzae pv. oryzae]
MVTATSIKLDDELKGRVQHLAESRRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT169003 NZ_CP076269:86237-86455 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A854CIX2